Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)
1_MVSWG 6_ RFICL 11_ VVVTM 16_ ATLSL 21_ ARPSF 26_ SLVED 31_ TTLEP 36_ EEPPT 41_ KYQIS 46_ QPEVY 51_ VAAPG 56_ ESLEV 61_ RCLLK 66_ DAAVI 71_ SWTKD 76_ GVHLG 81_ PNNRT 86_ VLIGE 91_ YLQIK 96_ GATPR 101_ DSGLY 106_ ACTAS 111_ RTVDS 116_ ETWYF 121_ MVNVT 126_ DAISS 131_ GDDED 136_ DTDGA 141_ EDFVS 146_ ENSNN 151_ KRAPY 156_ WTNTE 161_ KMEKR 166_ LHAVP 171_ AANTV 176_ KFRCP 181_ AGGNP 186_ MPTMR 191_ WLKNG 196_ KEFKQ 201_ EHRIG 206_ GYKVR 211_ NQHWS 216_ LIMES 221_ VVPSD 226_ KGNYT 231_ CVVEN 236_ EYGSI 241_ NHTYH 246_ LDVVE 251_ RSPHR 256_ PILQA 261_ GLPAN 266_ ASTVV 271_ GGDVE 276_ FVCKV 281_ YSDAQ 286_ PHIQW 291_ IKHVE 296_ KNGSK 301_ YGPDG 306_ LPYLK 311_ VLKAA 316_ GVNTT 321_ DKEIE 326_ VLYIR 331_ NVTFE 336_ DAGEY 341_ TCLAG 346_ NSIGI 351_ SFHSA 356_ WLTVL 361_ PAPGR 366_ EKEIT 371_ ASPDY 376_ LEIAI 381_ YCIGV 386_ FLIAC 391_ MVVTV 396_ ILCRM 401_ KNTTK 406_ KPDFS 411_ SQPAV 416_ HKLTK 421_ RIPLR 426_ RQVTV 431_ SAESS 436_ SSMNS 441_ NTPLV 446_ RITTR 451_ LSSTA 456_ DTPML 461_ AGVSE 466_ YELPE 471_ DPKWE 476_ FPRDK 481_ LTLGK 486_ PLGEG 491_ CFGQV 496_ VMAEA 501_ VGIDK 506_ DKPKE 511_ AVTVA 516_ VKMLK 521_ DDATE 526_ KDLSD 531_ LVSEM 536_ EMMKM 541_ IGKHK 546_ NIINL 551_ LGACT 556_ QDGPL 561_ YVIVE 566_ YASKG 571_ NLREY 576_ LRARR 581_ PPGME 586_ YSYDI 591_ NRVPE 596_ EQMTF 601_ KDLVS 606_ CTYQL 611_ ARGME 616_ YLASQ 621_ KCIHR 626_ DLAAR 631_ NVLVT 636_ ENNVM 641_ KIADF 646_ GLARD 651_ INNID 656_ YYKKT 661_ TNGRL 666_ PVKWM 671_ APEAL 676_ FDRVY 681_ THQSD 686_ VWSFG 691_ VLMWE 696_ IFTLG 701_ GSPYP 706_ GIPVE 711_ ELFKL 716_ LKEGH 721_ RMDKP 726_ ANCTN 731_ ELYMM 736_ MRDCW 741_ HAVPS 746_ QRPTF 751_ KQLVE 756_ DLDRI 761_ LTLTT 766_ NEEYL 771_ DLSQP 776_ LEQYS 781_ PSYPD 786_ TRSSC 791_ SSGDD 796_ SVFSP 801_ DPMPY 806_ EPCLP 811_ QYPHI 816_NGSVK
1: Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1