Bone sialoprotein 2 (Bone sialoprotein II) (BSP II) (Cell-binding sialoprotein) (Integrin-binding sialoprotein)
1_MKTAL 6_ ILLSI 11_ LGMAC 16_ AFSMK 21_ NLHRR 26_ VKIED 31_ SEENG 36_ VFKYR 41_ PRYYL 46_ YKHAY 51_ FYPHL 56_ KRFPV 61_ QGSSD 66_ SSEEN 71_ GDDSS 76_ EEEEE 81_ EEETS 86_ NEGEN 91_ NEESN 96_ EDEDS 101_ EAENT 106_ TLSAT 111_ TLGYG 116_ EDATP 121_ GTGYT 126_ GLAAI 131_ QLPKK 136_ AGDIT 141_ NKATK 146_ EKESD 151_ EEEEE 156_ EEEGN 161_ ENEES 166_ EAEVD 171_ ENEQG 176_ INGTS 181_ TNSTE 186_ AENGN 191_ GSSGG 196_ DNGEE 201_ GEEES 206_ VTGAN 211_ AEDTT 216_ ETGRQ 221_ GKGTS 226_ KTTTS 231_ PNGGF 236_ EPTTP 241_ PQVYR 246_ TTSPP 251_ FGKTT 256_ TVEYE 261_ GEYEY 266_ TGANE 271_ YDNGY 276_ EIYES 281_ ENGEP 286_ RGDNY 291_ RAYED 296_ EYSYF 301_ KGQGY 306_ DGYDG 311_QNYYH
1: Binds tightly to hydroxyapatite (PubMed:11459848). Appears to form an integral part of the mineralized matrix (PubMed:1818768). Probably important to cell-matrix interaction (PubMed:1818768). Promotes adhesion and migration of various cells via the alpha-V/beta-3 integrin receptor (ITGAV:ITGB3) (PubMed:10640428, PubMed:11459848, PubMed:24103036)