B-cell differentiation antigen CD72 (Lyb-2) (CD antigen CD72)
1_MAEAI 6_ TYADL 11_ RFVKA 16_ PLKKS 21_ ISSRL 26_ GQDPG 31_ ADDDG 36_ EITYE 41_ NVQVP 46_ AVLGV 51_ PSSLA 56_ SSVLG 61_ DKAAV 66_ KSEQP 71_ TASWR 76_ AVTSP 81_ AVGRI 86_ LPCRT 91_ TCLRY 96_ LLLGL 101_ LLTCL 106_ LLGVT 111_ AICLG 116_ VRYLQ 121_ VSQQL 126_ QQTNR 131_ VLEVT 136_ NSSLR 141_ QQLRL 146_ KITQL 151_ GQSAE 156_ DLQGS 161_ RRELA 166_ QSQEA 171_ LQVEQ 176_ RAHQA 181_ AEGQL 186_ QACQA 191_ DRQKT 196_ KETLQ 201_ SEEQQ 206_ RRALE 211_ QKLSN 216_ MENRL 221_ KPFFT 226_ CGSAD 231_ TCCPS 236_ GWIMH 241_ QKSCF 246_ YISLT 251_ SKNWQ 256_ ESQKQ 261_ CETLS 266_ SKLAT 271_ FSEIY 276_ PQSHS 281_ YYFLN 286_ SLLPN 291_ GGSGN 296_ SYWTG 301_ LSSNK 306_ DWKLT 311_ DDTQR 316_ TRTYA 321_ QSSKC 326_ NKVHK 331_ TWSWW 336_ TLESE 341_ SCRSS 346_ LPYIC 351_EMTAF
1: Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions. Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling. Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling. Also acts as a ligand for CD5 and thereby plays a critical role in maintaining regulatory T and B-cell homeostasis