Gene name: SDHB

Uniprot entry:

P21912

Protein names:

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1) (Iron-sulfur subunit of complex II) (Ip)

Protein sequence:

1_MAAVV 6_ ALSLR 11_ RRLPA 16_ TTLGG 21_ ACLQA 26_ SRGAQ 31_ TAAAT 36_ APRIK 41_ KFAIY 46_ RWDPD 51_ KAGDK 56_ PHMQT 61_ YEVDL 66_ NKCGP 71_ MVLDA 76_ LIKIK 81_ NEVDS 86_ TLTFR 91_ RSCRE 96_ GICGS 101_ CAMNI 106_ NGGNT 111_ LACTR 116_ RIDTN 121_ LNKVS 126_ KIYPL 131_ PHMYV 136_ IKDLV 141_ PDLSN 146_ FYAQY 151_ KSIEP 156_ YLKKK 161_ DESQE 166_ GKQQY 171_ LQSIE 176_ EREKL 181_ DGLYE 186_ CILCA 191_ CCSTS 196_ CPSYW 201_ WNGDK 206_ YLGPA 211_ VLMQA 216_ YRWMI 221_ DSRDD 226_ FTEER 231_ LAKLQ 236_ DPFSL 241_ YRCHT 246_ IMNCT 251_ RTCPK 256_ GLNPG 261_ KAIAE 266_ IKKMM 271_ATYKE

Protein annotations

Protein functions:

1: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:26925370, PubMed:27604842). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity)