D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor)
1_MGNRS 6_ TADAD 11_ GLLAG 16_ RGPAA 21_ GASAG 26_ ASAGL 31_ AGQGA 36_ AALVG 41_ GVLLI 46_ GAVLA 51_ GNSLV 56_ CVSVA 61_ TERAL 66_ QTPTN 71_ SFIVS 76_ LAAAD 81_ LLLAL 86_ LVLPL 91_ FVYSE 96_ VQGGA 101_ WLLSP 106_ RLCDA 111_ LMAMD 116_ VMLCT 121_ ASIFN 126_ LCAIS 131_ VDRFV 136_ AVAVP 141_ LRYNR 146_ QGGSR 151_ RQLLL 156_ IGATW 161_ LLSAA 166_ VAAPV 171_ LCGLN 176_ DVRGR 181_ DPAVC 186_ RLEDR 191_ DYVVY 196_ SSVCS 201_ FFLPC 206_ PLMLL 211_ LYWAT 216_ FRGLQ 221_ RWEVA 226_ RRAKL 231_ HGRAP 236_ RRPSG 241_ PGPPS 246_ PTPPA 251_ PRLPQ 256_ DPCGP 261_ DCAPP 266_ APGLP 271_ RGPCG 276_ PDCAP 281_ AAPSL 286_ PQDPC 291_ GPDCA 296_ PPAPG 301_ LPPDP 306_ CGSNC 311_ APPDA 316_ VRAAA 321_ LPPQT 326_ PPQTR 331_ RRRRA 336_ KITGR 341_ ERKAM 346_ RVLPV 351_ VVGAF 356_ LLCWT 361_ PFFVV 366_ HITQA 371_ LCPAC 376_ SVPPR 381_ LVSAV 386_ TWLGY 391_ VNSAL 396_ NPVIY 401_ TVFNA 406_ EFRNV 411_FRKAL
1: Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:16423344, PubMed:27659709, PubMed:29051383, PubMed:9003072). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:16423344, PubMed:27659709, PubMed:29051383, PubMed:7512953, PubMed:7643093). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity)