Cartilage matrix protein (Matrilin-1)
1_MRVLS 6_ GTSLM 11_ LCSLL 16_ LLLQA 21_ LCSPG 26_ LAPQS 31_ RGHLC 36_ RTRPT 41_ DLVFV 46_ VDSSR 51_ SVRPV 56_ EFEKV 61_ KVFLS 66_ QVIES 71_ LDVGP 76_ NATRV 81_ GMVNY 86_ ASTVK 91_ QEFSL 96_ RAHVS 101_ KAALL 106_ QAVRR 111_ IQPLS 116_ TGTMT 121_ GLAIQ 126_ FAITK 131_ AFGDA 136_ EGGRS 141_ RSPDI 146_ SKVVI 151_ VVTDG 156_ RPQDS 161_ VQDVS 166_ ARARA 171_ SGVEL 176_ FAIGV 181_ GSVDK 186_ ATLRQ 191_ IASEP 196_ QDEHV 201_ DYVES 206_ YSVIE 211_ KLSRK 216_ FQEAF 221_ CVVSD 226_ LCATG 231_ DHDCE 236_ QVCIS 241_ SPGSY 246_ TCACH 251_ EGFTL 256_ NSDGK 261_ TCNVC 266_ SGGGG 271_ SSATD 276_ LVFLI 281_ DGSKS 286_ VRPEN 291_ FELVK 296_ KFISQ 301_ IVDTL 306_ DVSDK 311_ LAQVG 316_ LVQYS 321_ SSVRQ 326_ EFPLG 331_ RFHTK 336_ KDIKA 341_ AVRNM 346_ SYMEK 351_ GTMTG 356_ AALKY 361_ LIDNS 366_ FTVSS 371_ GARPG 376_ AQKVG 381_ IVFTD 386_ GRSQD 391_ YINDA 396_ AKKAK 401_ DLGFK 406_ MFAVG 411_ VGNAV 416_ EDELR 421_ EIASE 426_ PVAEH 431_ YFYTA 436_ DFKTI 441_ NQIGK 446_ KLQKK 451_ ICVEE 456_ DPCAC 461_ ESLVK 466_ FQAKV 471_ EGLLQ 476_ ALTRK 481_ LEAVS 486_ KRLAI 491_LENTV
1: A major component of the extracellular matrix of non-articular cartilage (By similarity). Binds to type 2 collagens and forms long concatenated protein networks as part of the extracellular matrix (By similarity). Required for the network-like organization and bundling of collagen fibrils surrounding chondrocytes in the zones of maturation and hypertrophy (By similarity). Required for mechanotransduction and adaption to mechanical loading in cartilage chondrocytes, resulting in an increase in expression of the extracellular matrix components ACAN and COL2A1 (By similarity). Acts as a moderator of angiogenesis in response to injury (By similarity)