Gene name: COMT

Uniprot entry:

P21964

Protein names:

Catechol O-methyltransferase (EC 2.1.1.6)

Protein sequence:

1_MPEAP 6_ PLLLA 11_ AVLLG 16_ LVLLV 21_ VLLLL 26_ LRHWG 31_ WGLCL 36_ IGWNE 41_ FILQP 46_ IHNLL 51_ MGDTK 56_ EQRIL 61_ NHVLQ 66_ HAEPG 71_ NAQSV 76_ LEAID 81_ TYCEQ 86_ KEWAM 91_ NVGDK 96_ KGKIV 101_ DAVIQ 106_ EHQPS 111_ VLLEL 116_ GAYCG 121_ YSAVR 126_ MARLL 131_ SPGAR 136_ LITIE 141_ INPDC 146_ AAITQ 151_ RMVDF 156_ AGVKD 161_ KVTLV 166_ VGASQ 171_ DIIPQ 176_ LKKKY 181_ DVDTL 186_ DMVFL 191_ DHWKD 196_ RYLPD 201_ TLLLE 206_ ECGLL 211_ RKGTV 216_ LLADN 221_ VICPG 226_ APDFL 231_ AHVRG 236_ SSCFE 241_ CTHYQ 246_ SFLEY 251_ REVVD 256_ GLEKA 261_ IYKGP 266_GSEAG

Protein annotations

Protein functions:

1: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol