Bone morphogenetic protein 5 (BMP-5)
1_MHLTV 6_ FLLKG 11_ IVGFL 16_ WSCWV 21_ LVGYA 26_ KGGLG 31_ DNHVH 36_ SSFIY 41_ RRLRN 46_ HERRE 51_ IQREI 56_ LSILG 61_ LPHRP 66_ RPFSP 71_ GKQAS 76_ SAPLF 81_ MLDLY 86_ NAMTN 91_ EENPE 96_ ESEYS 101_ VRASL 106_ AEETR 111_ GARKG 116_ YPASP 121_ NGYPR 126_ RIQLS 131_ RTTPL 136_ TTQSP 141_ PLASL 146_ HDTNF 151_ LNDAD 156_ MVMSF 161_ VNLVE 166_ RDKDF 171_ SHQRR 176_ HYKEF 181_ RFDLT 186_ QIPHG 191_ EAVTA 196_ AEFRI 201_ YKDRS 206_ NNRFE 211_ NETIK 216_ ISIYQ 221_ IIKEY 226_ TNRDA 231_ DLFLL 236_ DTRKA 241_ QALDV 246_ GWLVF 251_ DITVT 256_ SNHWV 261_ INPQN 266_ NLGLQ 271_ LCAET 276_ GDGRS 281_ INVKS 286_ AGLVG 291_ RQGPQ 296_ SKQPF 301_ MVAFF 306_ KASEV 311_ LLRSV 316_ RAANK 321_ RKNQN 326_ RNKSS 331_ SHQDS 336_ SRMSS 341_ VGDYN 346_ TSEQK 351_ QACKK 356_ HELYV 361_ SFRDL 366_ GWQDW 371_ IIAPE 376_ GYAAF 381_ YCDGE 386_ CSFPL 391_ NAHMN 396_ ATNHA 401_ IVQTL 406_ VHLMF 411_ PDHVP 416_ KPCCA 421_ PTKLN 426_ AISVL 431_ YFDDS 436_ SNVIL 441_ KKYRN 446_MVVRS
1: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis (PubMed:11580864, PubMed:29321139). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:11580864). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:11580864, PubMed:29321139). Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation (PubMed:20402566). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed:30097509)