Bone morphogenetic protein 6 (BMP-6) (VG-1-related protein) (VG-1-R) (VGR-1)
1_MPGLG 6_ RRAQW 11_ LCWWW 16_ GLLCS 21_ CCGPP 26_ PLRPP 31_ LPAAA 36_ AAAAG 41_ GQLLG 46_ DGGSP 51_ GRTEQ 56_ PPPSP 61_ QSSSG 66_ FLYRR 71_ LKTQE 76_ KREMQ 81_ KEILS 86_ VLGLP 91_ HRPRP 96_ LHGLQ 101_ QPQPP 106_ ALRQQ 111_ EEQQQ 116_ QQQLP 121_ RGEPP 126_ PGRLK 131_ SAPLF 136_ MLDLY 141_ NALSA 146_ DNDED 151_ GASEG 156_ ERQQS 161_ WPHEA 166_ ASSSQ 171_ RRQPP 176_ PGAAH 181_ PLNRK 186_ SLLAP 191_ GSGSG 196_ GASPL 201_ TSAQD 206_ SAFLN 211_ DADMV 216_ MSFVN 221_ LVEYD 226_ KEFSP 231_ RQRHH 236_ KEFKF 241_ NLSQI 246_ PEGEV 251_ VTAAE 256_ FRIYK 261_ DCVMG 266_ SFKNQ 271_ TFLIS 276_ IYQVL 281_ QEHQH 286_ RDSDL 291_ FLLDT 296_ RVVWA 301_ SEEGW 306_ LEFDI 311_ TATSN 316_ LWVVT 321_ PQHNM 326_ GLQLS 331_ VVTRD 336_ GVHVH 341_ PRAAG 346_ LVGRD 351_ GPYDK 356_ QPFMV 361_ AFFKV 366_ SEVHV 371_ RTTRS 376_ ASSRR 381_ RQQSR 386_ NRSTQ 391_ SQDVA 396_ RVSSA 401_ SDYNS 406_ SELKT 411_ ACRKH 416_ ELYVS 421_ FQDLG 426_ WQDWI 431_ IAPKG 436_ YAANY 441_ CDGEC 446_ SFPLN 451_ AHMNA 456_ TNHAI 461_ VQTLV 466_ HLMNP 471_ EYVPK 476_ PCCAP 481_ TKLNA 486_ ISVLY 491_ FDDNS 496_ NVILK 501_ KYRNM 506_VVRAC
1: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation (PubMed:31019025). Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV (PubMed:26582087). Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3 (PubMed:30097509, PubMed:31800957). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B (PubMed:18070108). In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression (PubMed:33021694)