Oxysterol-binding protein 1
1_MAATE 6_ LRGVV 11_ GPGPA 16_ AIAAL 21_ GGGGA 26_ GPPVV 31_ GGGGG 36_ RGDAG 41_ PGSGA 46_ ASGTV 51_ VAAAA 56_ GGPGP 61_ GAGGV 66_ AAAGP 71_ APAPP 76_ TGGSG 81_ GSGAG 86_ GSGSA 91_ REGWL 96_ FKWTN 101_ YIKGY 106_ QRRWF 111_ VLSNG 116_ LLSYY 121_ RSKAE 126_ MRHTC 131_ RGTIN 136_ LATAN 141_ ITVED 146_ SCNFI 151_ ISNGG 156_ AQTYH 161_ LKASS 166_ EVERQ 171_ RWVTA 176_ LELAK 181_ AKAVK 186_ MLAES 191_ DESGD 196_ EESVS 201_ QTDKT 206_ ELQNT 211_ LRTLS 216_ SKVED 221_ LSTCN 226_ DLIAK 231_ HGTAL 236_ QRSLS 241_ ELESL 246_ KLPAE 251_ SNEKI 256_ KQVNE 261_ RATLF 266_ RITSN 271_ AMINA 276_ CRDFL 281_ MLAQT 286_ HSKKW 291_ QKSLQ 296_ YERDQ 301_ RIRLE 306_ ETLEQ 311_ LAKQH 316_ NHLER 321_ AFRGA 326_ TVLPA 331_ NTPGN 336_ VGSGK 341_ DQCCS 346_ GKGDM 351_ SDEDD 356_ ENEFF 361_ DAPEI 366_ ITMPE 371_ NLGHK 376_ RTGSN 381_ ISGAS 386_ SDISL 391_ DEQYK 396_ HQLEE 401_ TKKEK 406_ RTRIP 411_ YKPNY 416_ SLNLW 421_ SIMKN 426_ CIGKE 431_ LSKIP 436_ MPVNF 441_ NEPLS 446_ MLQRL 451_ TEDLE 456_ YHELL 461_ DRAAK 466_ CENSL 471_ EQLCY 476_ VAAFT 481_ VSSYS 486_ TTVFR 491_ TSKPF 496_ NPLLG 501_ ETFEL 506_ DRLEE 511_ NGYRS 516_ LCEQV 521_ SHHPP 526_ AAAHH 531_ AESKN 536_ GWTLR 541_ QEIKI 546_ TSKFR 551_ GKYLS 556_ IMPLG 561_ TIHCI 566_ FHATG 571_ HHYTW 576_ KKVTT 581_ TVHNI 586_ IVGKL 591_ WIDQS 596_ GEIDI 601_ VNHKT 606_ GDKCN 611_ LKFVP 616_ YSYFS 621_ RDVAR 626_ KVTGE 631_ VTDPS 636_ GKVHF 641_ ALLGT 646_ WDEKM 651_ ECFKV 656_ QPVIG 661_ ENGGD 666_ ARQRG 671_ HEAEE 676_ SRVML 681_ WKRNP 686_ LPKNA 691_ ENMYY 696_ FSELA 701_ LTLNA 706_ WESGT 711_ APTDS 716_ RLRPD 721_ QRLME 726_ NGRWD 731_ EANAE 736_ KQRLE 741_ EKQRL 746_ SRKKR 751_ EAEAM 756_ KATED 761_ GTPYD 766_ PYKAL 771_ WFERK 776_ KDPVT 781_ KELTH 786_ IYRGE 791_ YWECK 796_ EKQDW 801_SSCPD
1: Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749)