Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase)
1_MAWKS 6_ GGASH 11_ SELIH 16_ NLRKN 21_ GIIKT 26_ DKVFE 31_ VMLAT 36_ DRSHY 41_ AKCNP 46_ YMDSP 51_ QSIGF 56_ QATIS 61_ APHMH 66_ AYALE 71_ LLFDQ 76_ LHEGA 81_ KALDV 86_ GSGSG 91_ ILTAC 96_ FARMV 101_ GCTGK 106_ VIGID 111_ HIKEL 116_ VDDSV 121_ NNVRK 126_ DDPTL 131_ LSSGR 136_ VQLVV 141_ GDGRM 146_ GYAEE 151_ APYDA 156_ IHVGA 161_ AAPVV 166_ PQALI 171_ DQLKP 176_ GGRLI 181_ LPVGP 186_ AGGNQ 191_ MLEQY 196_ DKLQD 201_ GSIKM 206_ KPLMG 211_ VIYVP 216_ LTDKE 221_KQWSR
1: Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins (PubMed:3167043, PubMed:6469980). Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity)