Lactoperoxidase (LPO) (EC 1.11.1.7) (Salivary peroxidase) (SPO)
1_MRVLL 6_ HLPAL 11_ LASLI 16_ LLQAA 21_ ASTTR 26_ AQTTR 31_ TSAIS 36_ DTVSQ 41_ AKVQV 46_ NKAFL 51_ DSRTR 56_ LKTAM 61_ SSETP 66_ TSRQL 71_ SEYLK 76_ HAKGR 81_ TRTAI 86_ RNGQV 91_ WEESL 96_ KRLRQ 101_ KASLT 106_ NVTDP 111_ SLDLT 116_ SLSLE 121_ VGCGA 126_ PAPVV 131_ RCDPC 136_ SPYRT 141_ ITGDC 146_ NNRRK 151_ PALGA 156_ ANRAL 161_ ARWLP 166_ AEYED 171_ GLSLP 176_ FGWTP 181_ GKTRN 186_ GFPLP 191_ LAREV 196_ SNKIV 201_ GYLNE 206_ EGVLD 211_ QNRSL 216_ LFMQW 221_ GQIVD 226_ HDLDF 231_ APDTE 236_ LGSSE 241_ YSKAQ 246_ CDEYC 251_ IQGDN 256_ CFPIM 261_ FPPND 266_ PKAGT 271_ QGKCM 276_ PFFRA 281_ GFVCP 286_ TPPYK 291_ SLARE 296_ QINAL 301_ TSFLD 306_ ASFVY 311_ SSEPS 316_ LASRL 321_ RNLSS 326_ PLGLM 331_ AVNQE 336_ VSDHG 341_ LPYLP 346_ YDSKK 351_ PSPCE 356_ FINTT 361_ ARVPC 366_ FLAGD 371_ SRASE 376_ HILLA 381_ TSHTL 386_ FLREH 391_ NRLAR 396_ ELKRL 401_ NPQWD 406_ GEKLY 411_ QEARK 416_ ILGAF 421_ VQIIT 426_ FRDYL 431_ PILLG 436_ DHMQK 441_ WIPPY 446_ QGYSE 451_ SVDPR 456_ ISNVF 461_ TFAFR 466_ FGHLE 471_ VPSSM 476_ FRLDE 481_ NYQPW 486_ GPEPE 491_ LPLHT 496_ LFFNT 501_ WRMVK 506_ DGGID 511_ PLVRG 516_ LLAKK 521_ SKLMK 526_ QNKMM 531_ TGELR 536_ NKLFQ 541_ PTHRI 546_ HGFDL 551_ AAINT 556_ QRCRD 561_ HGQPG 566_ YNSWR 571_ AFCDL 576_ SQPQT 581_ LEELN 586_ TVLKS 591_ KMLAK 596_ KLLGL 601_ YGTPD 606_ NIDIW 611_ IGAIA 616_ EPLVE 621_ RGRVG 626_ PLLAC 631_ LLGKQ 636_ FQQIR 641_ DGDRF 646_ WWENP 651_ GVFTN 656_ EQKDS 661_ LQKMS 666_ FSRLV 671_ CDNTR 676_ ITKVP 681_ RDPFW 686_ ANSYP 691_ YDFVD 696_ CSAID 701_ KLDLS 706_PWASV
1: Heme-containing oxidoreductase which catalyzes the conversion of thiocyanate (SCN(-)) into antimicrobial agent hypothiocyanous acid (OSCN(-)) in the presence of hydrogen peroxide (H2O2) (By similarity). Also involved in the conversion of iodide (I(-)) into hypoiodite (IO(-)) in the presence of H2O2 (By similarity). Responsible for the inactivation of a wide range of micro-organisms and hence, important component of defense mechanism (PubMed:12626341). Shows antibacterial properties against Pseudomonas aeruginosa (PubMed:12626341). The lactoperoxidase-SCN(-)-H2O2 system shows antibacterial properties against Burkholderia cepacia and Haemophilus influenzae in vitro (PubMed:12626341). Present in mammary and salivary gland secretions and may contribute to airway host defense against infection (PubMed:12626341). May contribute to maintaining an appropriate H2O2 cellular level, therefore protecting cells from H2O2-caused injuries and inflammation (By similarity)