Alpha-(1,3)-fucosyltransferase 4 (4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase) (EC 2.4.1.152) (ELAM-1 ligand fucosyltransferase) (Fucosyltransferase 4) (Fucosyltransferase IV) (Fuc-TIV) (FucT-IV) (Galactoside 3-L-fucosyltransferase)
1_MRRLW 6_ GAARK 11_ PSGAG 16_ WEKEW 21_ AEAPQ 26_ EAPGA 31_ WSGRL 36_ GPGRS 41_ GRKGR 46_ AVPGW 51_ ASWPA 56_ HLALA 61_ ARPAR 66_ HLGGA 71_ GQGPR 76_ PLHSG 81_ TAPFH 86_ SRASG 91_ ERQRR 96_ LEPQL 101_ QHESR 106_ CRSST 111_ PADAW 116_ RAEAA 121_ LPVRA 126_ MGAPW 131_ GSPTA 136_ AAGGR 141_ RGWRR 146_ GRGLP 151_ WTVCV 156_ LAAAG 161_ LTCTA 166_ LITYA 171_ CWGQL 176_ PPLPW 181_ ASPTP 186_ SRPVG 191_ VLLWW 196_ EPFGG 201_ RDSAP 206_ RPPPD 211_ CRLRF 216_ NISGC 221_ RLLTD 226_ RASYG 231_ EAQAV 236_ LFHHR 241_ DLVKG 246_ PPDWP 251_ PPWGI 256_ QAHTA 261_ EEVDL 266_ RVLDY 271_ EEAAA 276_ AAEAL 281_ ATSSP 286_ RPPGQ 291_ RWVWM 296_ NFESP 301_ SHSPG 306_ LRSLA 311_ SNLFN 316_ WTLSY 321_ RADSD 326_ VFVPY 331_ GYLYP 336_ RSHPG 341_ DPPSG 346_ LAPPL 351_ SRKQG 356_ LVAWV 361_ VSHWD 366_ ERQAR 371_ VRYYH 376_ QLSQH 381_ VTVDV 386_ FGRGG 391_ PGQPV 396_ PEIGL 401_ LHTVA 406_ RYKFY 411_ LAFEN 416_ SQHLD 421_ YITEK 426_ LWRNA 431_ LLAGA 436_ VPVVL 441_ GPDRA 446_ NYERF 451_ VPRGA 456_ FIHVD 461_ DFPSA 466_ SSLAS 471_ YLLFL 476_ DRNPA 481_ VYRRY 486_ FHWRR 491_ SYAVH 496_ ITSFW 501_ DEPWC 506_ RVCQA 511_ VQRAG 516_ DRPKS 521_IRNLA
1: Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins (PubMed:1702034, PubMed:1716630, PubMed:29593094). Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins (PubMed:1716630, PubMed:29593094). Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis (By similarity). In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE (PubMed:11278338, PubMed:1716630)
2: Does not generate Lewis X antigens