Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)]
1_MATAE 6_ VLNIG 11_ KKLYE 16_ GKTKE 21_ VYELL 26_ DSPGK 31_ VLLQS 36_ KDQIT 41_ AGNAA 46_ RKNHL 51_ EGKAA 56_ ISNKI 61_ TSCIF 66_ QLLQE 71_ AGIKT 76_ AFTRK 81_ CGETA 86_ FIAPQ 91_ CEMIP 96_ IEWVC 101_ RRIAT 106_ GSFLK 111_ RNPGV 116_ KEGYK 121_ FYPPK 126_ VELFF 131_ KDDAN 136_ NDPQW 141_ SEEQL 146_ IAAKF 151_ CFAGL 156_ LIGQT 161_ EVDIM 166_ SHATQ 171_ AIFEI 176_ LEKSW 181_ LPQNC 186_ TLVDM 191_ KIEFG 196_ VDVTT 201_ KEIVL 206_ ADVID 211_ NDSWR 216_ LWPSG 221_ DRSQQ 226_ KDKQS 231_ YRDLK 236_ EVTPE 241_ GLQMV 246_ KKNFE 251_ WVAER 256_ VELLL 261_ KSESQ 266_ CRVVV 271_ LMGST 276_ SDLGH 281_ CEKIK 286_ KACGN 291_ FGIPC 296_ ELRVT 301_ SAHKG 306_ PDETL 311_ RIKAE 316_ YEGDG 321_ IPTVF 326_ VAVAG 331_ RSNGL 336_ GPVMS 341_ GNTAY 346_ PVISC 351_ PPLTP 356_ DWGVQ 361_ DVWSS 366_ LRLPS 371_ GLGCS 376_ TVLSP 381_ EGSAQ 386_ FAAQI 391_ FGLSN 396_ HLVWS 401_ KLRAS 406_ ILNTW 411_ ISLKQ 416_ADKKI
1: Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway