Sterol carrier protein 2 (SCP-2) (Acetyl-CoA C-myristoyltransferase) (EC 2.3.1.155) (Non-specific lipid-transfer protein) (NSL-TP) (Propanoyl-CoA C-acyltransferase) (EC 2.3.1.176) (SCP-2/3-oxoacyl-CoA thiolase) (SCP-2/thiolase) (EC 2.3.1.16) (SCP-chi) (SCPX) (Sterol carrier protein X) (SCP-X)
1_MSSSP 6_ WEPAT 11_ LRRVF 16_ VVGVG 21_ MTKFV 26_ KPGAE 31_ NSRDY 36_ PDLAE 41_ EAGKK 46_ ALADA 51_ QIPYS 56_ AVDQA 61_ CVGYV 66_ FGDST 71_ CGQRA 76_ IYHSL 81_ GMTGI 86_ PIINV 91_ NNNCA 96_ TGSTA 101_ LFMAR 106_ QLIQG 111_ GVAEC 116_ VLALG 121_ FEKMS 126_ KGSLG 131_ IKFSD 136_ RTIPT 141_ DKHVD 146_ LLINK 151_ YGLSA 156_ HPVAP 161_ QMFGY 166_ AGKEH 171_ MEKYG 176_ TKIEH 181_ FAKIG 186_ WKNHK 191_ HSVNN 196_ PYSQF 201_ QDEYS 206_ LDEVM 211_ ASKEV 216_ FDFLT 221_ ILQCC 226_ PTSDG 231_ AAAAI 236_ LASEA 241_ FVQKY 246_ GLQSK 251_ AVEIL 256_ AQEMM 261_ TDLPS 266_ SFEEK 271_ SIIKM 276_ VGFDM 281_ SKEAA 286_ RKCYE 291_ KSGLT 296_ PNDID 301_ VIELH 306_ DCFST 311_ NELLT 316_ YEALG 321_ LCPEG 326_ QGATL 331_ VDRGD 336_ NTYGG 341_ KWVIN 346_ PSGGL 351_ ISKGH 356_ PLGAT 361_ GLAQC 366_ AELCW 371_ QLRGE 376_ AGKRQ 381_ VPGAK 386_ VALQH 391_ NLGIG 396_ GAVVV 401_ TLYKM 406_ GFPEA 411_ ASSFR 416_ THQIE 421_ AVPTS 426_ SASDG 431_ FKANL 436_ VFKEI 441_ EKKLE 446_ EEGEQ 451_ FVKKI 456_ GGIFA 461_ FKVKD 466_ GPGGK 471_ EATWV 476_ VDVKN 481_ GKGSV 486_ LPNSD 491_ KKADC 496_ TITMA 501_ DSDFL 506_ ALMTG 511_ KMNPQ 516_ SAFFQ 521_ GKLKI 526_ TGNMG 531_ LAMKL 536_ QNLQL 541_QPGNA
1: Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids (PubMed:10706581). Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (PubMed:10706581). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity)
2: Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis (PubMed:17157249, PubMed:7642518, PubMed:8300590). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol (By similarity). Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity)