UDP-glucuronosyltransferase 1A1 (UGT1A1) (EC 2.4.1.17) (Bilirubin-specific UDPGT isozyme 1) (hUG-BR1) (UDP-glucuronosyltransferase 1-1) (UDPGT 1-1) (UGT1*1) (UGT1-01) (UGT1.1) (UDP-glucuronosyltransferase 1A isoform 1)
1_MAVES 6_ QGGRP 11_ LVLGL 16_ LLCVL 21_ GPVVS 26_ HAGKI 31_ LLIPV 36_ DGSHW 41_ LSMLG 46_ AIQQL 51_ QQRGH 56_ EIVVL 61_ APDAS 66_ LYIRD 71_ GAFYT 76_ LKTYP 81_ VPFQR 86_ EDVKE 91_ SFVSL 96_ GHNVF 101_ ENDSF 106_ LQRVI 111_ KTYKK 116_ IKKDS 121_ AMLLS 126_ GCSHL 131_ LHNKE 136_ LMASL 141_ AESSF 146_ DVMLT 151_ DPFLP 156_ CSPIV 161_ AQYLS 166_ LPTVF 171_ FLHAL 176_ PCSLE 181_ FEATQ 186_ CPNPF 191_ SYVPR 196_ PLSSH 201_ SDHMT 206_ FLQRV 211_ KNMLI 216_ AFSQN 221_ FLCDV 226_ VYSPY 231_ ATLAS 236_ EFLQR 241_ EVTVQ 246_ DLLSS 251_ ASVWL 256_ FRSDF 261_ VKDYP 266_ RPIMP 271_ NMVFV 276_ GGINC 281_ LHQNP 286_ LSQEF 291_ EAYIN 296_ ASGEH 301_ GIVVF 306_ SLGSM 311_ VSEIP 316_ EKKAM 321_ AIADA 326_ LGKIP 331_ QTVLW 336_ RYTGT 341_ RPSNL 346_ ANNTI 351_ LVKWL 356_ PQNDL 361_ LGHPM 366_ TRAFI 371_ THAGS 376_ HGVYE 381_ SICNG 386_ VPMVM 391_ MPLFG 396_ DQMDN 401_ AKRME 406_ TKGAG 411_ VTLNV 416_ LEMTS 421_ EDLEN 426_ ALKAV 431_ INDKS 436_ YKENI 441_ MRLSS 446_ LHKDR 451_ PVEPL 456_ DLAVF 461_ WVEFV 466_ MRHKG 471_ APHLR 476_ PAAHD 481_ LTWYQ 486_ YHSLD 491_ VIGFL 496_ LAVVL 501_ TVAFI 506_ TFKCC 511_ AYGYR 516_ KCLGK 521_ KGRVK 526_KAHKS
1: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15472229, PubMed:18004206, PubMed:18004212, PubMed:18719240, PubMed:19830808, PubMed:23288867, PubMed:15231852, PubMed:21422672, PubMed:38211441). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004206, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (PubMed:15472229, PubMed:18719240, PubMed:23288867). Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates (PubMed:17187418, PubMed:18004206, PubMed:19830808, PubMed:24525562). Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE, 20-HETE, PGB1 and F2-isoprostane (8-iso-PGF2alpha) (PubMed:15231852, PubMed:38211441). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group (PubMed:21422672). Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:18004212, PubMed:20610558)
2: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1