UDP-glucuronosyltransferase 1A4 (UGT1A4) (EC 2.4.1.17) (Bilirubin-specific UDPGT isozyme 2) (hUG-BR2) (UDP-glucuronosyltransferase 1-4) (UDPGT 1-4) (UGT1*4) (UGT1-04) (UGT1.4) (UDP-glucuronosyltransferase 1-D) (UGT-1D) (UGT1D)
1_MARGL 6_ QVPLP 11_ RLATG 16_ LLLLL 21_ SVQPW 26_ AESGK 31_ VLVVP 36_ TDGSP 41_ WLSMR 46_ EALRE 51_ LHARG 56_ HQAVV 61_ LTPEV 66_ NMHIK 71_ EEKFF 76_ TLTAY 81_ AVPWT 86_ QKEFD 91_ RVTLG 96_ YTQGF 101_ FETEH 106_ LLKRY 111_ SRSMA 116_ IMNNV 121_ SLALH 126_ RCCVE 131_ LLHNE 136_ ALIRH 141_ LNATS 146_ FDVVL 151_ TDPVN 156_ LCGAV 161_ LAKYL 166_ SIPAV 171_ FFWRY 176_ IPCDL 181_ DFKGT 186_ QCPNP 191_ SSYIP 196_ KLLTT 201_ NSDHM 206_ TFLQR 211_ VKNML 216_ YPLAL 221_ SYICH 226_ TFSAP 231_ YASLA 236_ SELFQ 241_ REVSV 246_ VDLVS 251_ YASVW 256_ LFRGD 261_ FVMDY 266_ PRPIM 271_ PNMVF 276_ IGGIN 281_ CANGK 286_ PLSQE 291_ FEAYI 296_ NASGE 301_ HGIVV 306_ FSLGS 311_ MVSEI 316_ PEKKA 321_ MAIAD 326_ ALGKI 331_ PQTVL 336_ WRYTG 341_ TRPSN 346_ LANNT 351_ ILVKW 356_ LPQND 361_ LLGHP 366_ MTRAF 371_ ITHAG 376_ SHGVY 381_ ESICN 386_ GVPMV 391_ MMPLF 396_ GDQMD 401_ NAKRM 406_ ETKGA 411_ GVTLN 416_ VLEMT 421_ SEDLE 426_ NALKA 431_ VINDK 436_ SYKEN 441_ IMRLS 446_ SLHKD 451_ RPVEP 456_ LDLAV 461_ FWVEF 466_ VMRHK 471_ GAPHL 476_ RPAAH 481_ DLTWY 486_ QYHSL 491_ DVIGF 496_ LLAVV 501_ LTVAF 506_ ITFKC 511_ CAYGY 516_ RKCLG 521_ KKGRV 526_KKAHK
1: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18177842, PubMed:24641623, PubMed:15231852). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18177842). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3 essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623). Also glucuronidates the biologically active form of vitamin D3, calcitriol, probably leading to its biliary transport and intestinal reabsorption (PubMed:18177842). Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE, 20-HETE and PGB1 (PubMed:15231852)
2: Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1