Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)
1_MSSSP 6_ LSKKR 11_ RVSGP 16_ DPKPG 21_ SNCSP 26_ AQSVL 31_ SEVPS 36_ VPTNG 41_ MAKNG 46_ SEADI 51_ DEGLY 56_ SRQLY 61_ VLGHE 66_ AMKRL 71_ QTSSV 76_ LVSGL 81_ RGLGV 86_ EIAKN 91_ IILGG 96_ VKAVT 101_ LHDQG 106_ TAQWA 111_ DLSSQ 116_ FYLRE 121_ EDIGK 126_ NRAEV 131_ SQPRL 136_ AELNS 141_ YVPVT 146_ AYTGP 151_ LVEDF 156_ LSGFQ 161_ VVVLT 166_ NTPLE 171_ DQLRV 176_ GEFCH 181_ NRGIK 186_ LVVAD 191_ TRGLF 196_ GQLFC 201_ DFGEE 206_ MILTD 211_ SNGEQ 216_ PLSAM 221_ VSMVT 226_ KDNPG 231_ VVTCL 236_ DEARH 241_ GFESG 246_ DFVSF 251_ SEVQG 256_ MVELN 261_ GNQPM 266_ EIKVL 271_ GPYTF 276_ SICDT 281_ SNFSD 286_ YIRGG 291_ IVSQV 296_ KVPKK 301_ ISFKS 306_ LVASL 311_ AEPDF 316_ VVTDF 321_ AKFSR 326_ PAQLH 331_ IGFQA 336_ LHQFC 341_ AQHGR 346_ PPRPR 351_ NEEDA 356_ AELVA 361_ LAQAV 366_ NARAL 371_ PAVQQ 376_ NNLDE 381_ DLIRK 386_ LAYVA 391_ AGDLA 396_ PINAF 401_ IGGLA 406_ AQEVM 411_ KACSG 416_ KFMPI 421_ MQWLY 426_ FDALE 431_ CLPED 436_ KEVLT 441_ EDKCL 446_ QRQNR 451_ YDGQV 456_ AVFGS 461_ DLQEK 466_ LGKQK 471_ YFLVG 476_ AGAIG 481_ CELLK 486_ NFAMI 491_ GLGCG 496_ EGGEI 501_ IVTDM 506_ DTIEK 511_ SNLNR 516_ QFLFR 521_ PWDVT 526_ KLKSD 531_ TAAAA 536_ VRQMN 541_ PHIRV 546_ TSHQN 551_ RVGPD 556_ TERIY 561_ DDDFF 566_ QNLDG 571_ VANAL 576_ DNVDA 581_ RMYMD 586_ RRCVY 591_ YRKPL 596_ LESGT 601_ LGTKG 606_ NVQVV 611_ IPFLT 616_ ESYSS 621_ SQDPP 626_ EKSIP 631_ ICTLK 636_ NFPNA 641_ IEHTL 646_ QWARD 651_ EFEGL 656_ FKQPA 661_ ENVNQ 666_ YLTDP 671_ KFVER 676_ TLRLA 681_ GTQPL 686_ EVLEA 691_ VQRSL 696_ VLQRP 701_ QTWAD 706_ CVTWA 711_ CHHWH 716_ TQYSN 721_ NIRQL 726_ LHNFP 731_ PDQLT 736_ SSGAP 741_ FWSGP 746_ KRCPH 751_ PLTFD 756_ VNNPL 761_ HLDYV 766_ MAAAN 771_ LFAQT 776_ YGLTG 781_ SQDRA 786_ AVATF 791_ LQSVQ 796_ VPEFT 801_ PKSGV 806_ KIHVS 811_ DQELQ 816_ SANAS 821_ VDDSR 826_ LEELK 831_ ATLPS 836_ PDKLP 841_ GFKMY 846_ PIDFE 851_ KDDDS 856_ NFHMD 861_ FIVAA 866_ SNLRA 871_ ENYDI 876_ PSADR 881_ HKSKL 886_ IAGKI 891_ IPAIA 896_ TTTAA 901_ VVGLV 906_ CLELY 911_ KVVQG 916_ HRQLD 921_ SYKNG 926_ FLNLA 931_ LPFFG 936_ FSEPL 941_ AAPRH 946_ QYYNQ 951_ EWTLW 956_ DRFEV 961_ QGLQP 966_ NGEEM 971_ TLKQF 976_ LDYFK 981_ TEHKL 986_ EITML 991_ SQGVS 996_ MLYSF 1001_ FMPAA 1006_ KLKER 1011_ LDQPM 1016_ TEIVS 1021_ RVSKR 1026_ KLGRH 1031_ VRALV 1036_ LELCC 1041_ NDESG 1046_ EDVEV 1051_PYVRY
1: Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334)