Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2)
1_MANLE 6_ RTFIA 11_ IKPDG 16_ VQRGL 21_ VGEII 26_ KRFEQ 31_ KGFRL 36_ VAMKF 41_ LRASE 46_ EHLKQ 51_ HYIDL 56_ KDRPF 61_ FPGLV 66_ KYMNS 71_ GPVVA 76_ MVWEG 81_ LNVVK 86_ TGRVM 91_ LGETN 96_ PADSK 101_ PGTIR 106_ GDFCI 111_ QVGRN 116_ IIHGS 121_ DSVKS 126_ AEKEI 131_ SLWFK 136_ PEELV 141_ DYKSC 146_AHDWV
1: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:19435876, PubMed:8392752). Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1) (PubMed:19435876). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041). Exhibits histidine protein kinase activity (PubMed:20946858)