Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
1_MRLLL 6_ ALLGV 11_ LLSVP 16_ GPPVL 21_ SLEAS 26_ EEVEL 31_ EPCLA 36_ PSLEQ 41_ QEQEL 46_ TVALG 51_ QPVRL 56_ CCGRA 61_ ERGGH 66_ WYKEG 71_ SRLAP 76_ AGRVR 81_ GWRGR 86_ LEIAS 91_ FLPED 96_ AGRYL 101_ CLARG 106_ SMIVL 111_ QNLTL 116_ ITGDS 121_ LTSSN 126_ DDEDP 131_ KSHRD 136_ PSNRH 141_ SYPQQ 146_ APYWT 151_ HPQRM 156_ EKKLH 161_ AVPAG 166_ NTVKF 171_ RCPAA 176_ GNPTP 181_ TIRWL 186_ KDGQA 191_ FHGEN 196_ RIGGI 201_ RLRHQ 206_ HWSLV 211_ MESVV 216_ PSDRG 221_ TYTCL 226_ VENAV 231_ GSIRY 236_ NYLLD 241_ VLERS 246_ PHRPI 251_ LQAGL 256_ PANTT 261_ AVVGS 266_ DVELL 271_ CKVYS 276_ DAQPH 281_ IQWLK 286_ HIVIN 291_ GSSFG 296_ ADGFP 301_ YVQVL 306_ KTADI 311_ NSSEV 316_ EVLYL 321_ RNVSA 326_ EDAGE 331_ YTCLA 336_ GNSIG 341_ LSYQS 346_ AWLTV 351_ LPEED 356_ PTWTA 361_ AAPEA 366_ RYTDI 371_ ILYAS 376_ GSLAL 381_ AVLLL 386_ LAGLY 391_ RGQAL 396_ HGRHP 401_ RPPAT 406_ VQKLS 411_ RFPLA 416_ RQFSL 421_ ESGSS 426_ GKSSS 431_ SLVRG 436_ VRLSS 441_ SGPAL 446_ LAGLV 451_ SLDLP 456_ LDPLW 461_ EFPRD 466_ RLVLG 471_ KPLGE 476_ GCFGQ 481_ VVRAE 486_ AFGMD 491_ PARPD 496_ QASTV 501_ AVKML 506_ KDNAS 511_ DKDLA 516_ DLVSE 521_ MEVMK 526_ LIGRH 531_ KNIIN 536_ LLGVC 541_ TQEGP 546_ LYVIV 551_ ECAAK 556_ GNLRE 561_ FLRAR 566_ RPPGP 571_ DLSPD 576_ GPRSS 581_ EGPLS 586_ FPVLV 591_ SCAYQ 596_ VARGM 601_ QYLES 606_ RKCIH 611_ RDLAA 616_ RNVLV 621_ TEDNV 626_ MKIAD 631_ FGLAR 636_ GVHHI 641_ DYYKK 646_ TSNGR 651_ LPVKW 656_ MAPEA 661_ LFDRV 666_ YTHQS 671_ DVWSF 676_ GILLW 681_ EIFTL 686_ GGSPY 691_ PGIPV 696_ EELFS 701_ LLREG 706_ HRMDR 711_ PPHCP 716_ PELYG 721_ LMREC 726_ WHAAP 731_ SQRPT 736_ FKQLV 741_ EALDK 746_ VLLAV 751_ SEEYL 756_ DLRLT 761_ FGPYS 766_ PSGGD 771_ ASSTC 776_ SSSDS 781_ VFSHD 786_ PLPLG 791_ SSSFP 796_FGSGV
1: Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling