Potassium voltage-gated channel subfamily A member 5 (HPCN1) (Voltage-gated potassium channel HK2) (Voltage-gated potassium channel subunit Kv1.5)
1_MEIAL 6_ VPLEN 11_ GGAMT 16_ VRGGD 21_ EARAG 26_ CGQAT 31_ GGELQ 36_ CPPTA 41_ GLSDG 46_ PKEPA 51_ PKGRG 56_ AQRDA 61_ DSGVR 66_ PLPPL 71_ PDPGV 76_ RPLPP 81_ LPEEL 86_ PRPRR 91_ PPPED 96_ EEEEG 101_ DPGLG 106_ TVEDQ 111_ ALGTA 116_ SLHHQ 121_ RVHIN 126_ ISGLR 131_ FETQL 136_ GTLAQ 141_ FPNTL 146_ LGDPA 151_ KRLRY 156_ FDPLR 161_ NEYFF 166_ DRNRP 171_ SFDGI 176_ LYYYQ 181_ SGGRL 186_ RRPVN 191_ VSLDV 196_ FADEI 201_ RFYQL 206_ GDEAM 211_ ERFRE 216_ DEGFI 221_ KEEEK 226_ PLPRN 231_ EFQRQ 236_ VWLIF 241_ EYPES 246_ SGSAR 251_ AIAIV 256_ SVLVI 261_ LISII 266_ TFCLE 271_ TLPEF 276_ RDERE 281_ LLRHP 286_ PAPHQ 291_ PPAPA 296_ PGANG 301_ SGVMA 306_ PPSGP 311_ TVAPL 316_ LPRTL 321_ ADPFF 326_ IVETT 331_ CVIWF 336_ TFELL 341_ VRFFA 346_ CPSKA 351_ GFSRN 356_ IMNII 361_ DVVAI 366_ FPYFI 371_ TLGTE 376_ LAEQQ 381_ PGGGG 386_ GGQNG 391_ QQAMS 396_ LAILR 401_ VIRLV 406_ RVFRI 411_ FKLSR 416_ HSKGL 421_ QILGK 426_ TLQAS 431_ MRELG 436_ LLIFF 441_ LFIGV 446_ ILFSS 451_ AVYFA 456_ EADNQ 461_ GTHFS 466_ SIPDA 471_ FWWAV 476_ VTMTT 481_ VGYGD 486_ MRPIT 491_ VGGKI 496_ VGSLC 501_ AIAGV 506_ LTIAL 511_ PVPVI 516_ VSNFN 521_ YFYHR 526_ ETDHE 531_ EPAVL 536_ KEEQG 541_ TQSQG 546_ PGLDR 551_ GVQRK 556_ VSGSR 561_ GSFCK 566_ AGGTL 571_ ENADS 576_ ARRGS 581_ CPLEK 586_ CNVKA 591_ KSNVD 596_ LRRSL 601_ YALCL 606_DTSRE
1: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:12130714, PubMed:8505626). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). May play a role in regulating the secretion of insulin in normal pancreatic islets
2: Exhibits a faster depolarization rate, reduced voltage-dependent recovery from inactivation and an excessive cumulative inactivation