Histone H1t (Testicular H1 histone)
1_MSETV 6_ PAASA 11_ SAGVA 16_ AMEKL 21_ PTKKR 26_ GRKPA 31_ GLISA 36_ SRKVP 41_ NLSVS 46_ KLITE 51_ ALSVS 56_ QERVG 61_ MSLVA 66_ LKKAL 71_ AAAGY 76_ DVEKN 81_ NSRIK 86_ LSLKS 91_ LVNKG 96_ ILVQT 101_ RGTGA 106_ SGSFK 111_ LSKKV 116_ IPKST 121_ RSKAK 126_ KSVSA 131_ KTKKL 136_ VLSRD 141_ SKSPK 146_ TAKTN 151_ KRAKK 156_ PRATT 161_ PKTVR 166_ SGRKA 171_ KGAKG 176_ KQQQK 181_ SPVKA 186_ RASKS 191_ KLTQH 196_ HEVNV 201_RKATS
1: Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable)