5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS-E) (EC 2.3.1.37) (5-aminolevulinic acid synthase 2) (Delta-ALA synthase 2) (Delta-aminolevulinate synthase 2)
1_MVTAA 6_ MLLQC 11_ CPVLA 16_ RGPTS 21_ LLGKV 26_ VKTHQ 31_ FLFGI 36_ GRCPI 41_ LATQG 46_ PNCSQ 51_ IHLKA 56_ TKAGG 61_ DSPSW 66_ AKGHC 71_ PFMLS 76_ ELQDG 81_ KSKIV 86_ QKAAP 91_ EVQED 96_ VKAFK 101_ TDLPS 106_ SLVSV 111_ SLRKP 116_ FSGPQ 121_ EQEQI 126_ SGKVT 131_ HLIQN 136_ NMPGN 141_ YVFSY 146_ DQFFR 151_ DKIME 156_ KKQDH 161_ TYRVF 166_ KTVNR 171_ WADAY 176_ PFAQH 181_ FSEAS 186_ VASKD 191_ VSVWC 196_ SNDYL 201_ GMSRH 206_ PQVLQ 211_ ATQET 216_ LQRHG 221_ AGAGG 226_ TRNIS 231_ GTSKF 236_ HVELE 241_ QELAE 246_ LHQKD 251_ SALLF 256_ SSCFV 261_ ANDST 266_ LFTLA 271_ KILPG 276_ CEIYS 281_ DAGNH 286_ ASMIQ 291_ GIRNS 296_ GAAKF 301_ VFRHN 306_ DPDHL 311_ KKLLE 316_ KSNPK 321_ IPKIV 326_ AFETV 331_ HSMDG 336_ AICPL 341_ EELCD 346_ VSHQY 351_ GALTF 356_ VDEVH 361_ AVGLY 366_ GSRGA 371_ GIGER 376_ DGIMH 381_ KIDII 386_ SGTLG 391_ KAFGC 396_ VGGYI 401_ ASTRD 406_ LVDMV 411_ RSYAA 416_ GFIFT 421_ TSLPP 426_ MVLSG 431_ ALESV 436_ RLLKG 441_ EEGQA 446_ LRRAH 451_ QRNVK 456_ HMRQL 461_ LMDRG 466_ LPVIP 471_ CPSHI 476_ IPIRV 481_ GNAAL 486_ NSKLC 491_ DLLLS 496_ KHGIY 501_ VQAIN 506_ YPTVP 511_ RGEEL 516_ LRLAP 521_ SPHHS 526_ PQMME 531_ DFVEK 536_ LLLAW 541_ TAVGL 546_ PLQDV 551_ SVAAC 556_ NFCRR 561_ PVHFE 566_ LMSEW 571_ ERSYF 576_ GNMGP 581_QYVTT
1: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products (PubMed:14643893, PubMed:21252495, PubMed:21309041, PubMed:21653323, PubMed:32499479, PubMed:34492704). Contributes significantly to heme formation during erythropoiesis (PubMed:2050125)
2: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products (PubMed:14643893). Catalytic activity is 75-85% of isoform 1 activity (PubMed:14643893)
3: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products (PubMed:14643893). Catalytic activity is 65-75% of isoform 1 activity (PubMed:14643893)