NADPH:adrenodoxin oxidoreductase, mitochondrial (AR) (Adrenodoxin reductase) (EC 1.18.1.6) (Ferredoxin--NADP(+) reductase) (Ferredoxin reductase)
1_MASRC 6_ WRWWG 11_ WSAWP 16_ RTRLP 21_ PAGST 26_ PSFCH 31_ HFSTQ 36_ EKTPQ 41_ ICVVG 46_ SGPAG 51_ FYTAQ 56_ HLLKH 61_ PQAHV 66_ DIYEK 71_ QPVPF 76_ GLVRF 81_ GVAPD 86_ HPEVK 91_ NVINT 96_ FTQTA 101_ HSGRC 106_ AFWGN 111_ VEVGR 116_ DVTVP 121_ ELREA 126_ YHAVV 131_ LSYGA 136_ EDHRA 141_ LEIPG 146_ EELPG 151_ VCSAR 156_ AFVGW 161_ YNGLP 166_ ENQEL 171_ EPDLS 176_ CDTAV 181_ ILGQG 186_ NVALD 191_ VARIL 196_ LTPPE 201_ HLERT 206_ DITKA 211_ ALGVL 216_ RQSRV 221_ KTVWL 226_ VGRRG 231_ PLQVA 236_ FTIKE 241_ LREMI 246_ QLPGA 251_ RPILD 256_ PVDFL 261_ GLQDK 266_ IKEVP 271_ RPRKR 276_ LTELL 281_ LRTAT 286_ EKPGP 291_ AEAAR 296_ QASAS 301_ RAWGL 306_ RFFRS 311_ PQQVL 316_ PSPDG 321_ RRAAG 326_ VRLAV 331_ TRLEG 336_ VDEAT 341_ RAVPT 346_ GDMED 351_ LPCGL 356_ VLSSI 361_ GYKSR 366_ PVDPS 371_ VPFDS 376_ KLGVI 381_ PNVEG 386_ RVMDV 391_ PGLYC 396_ SGWVK 401_ RGPTG 406_ VIATT 411_ MTDSF 416_ LTGQM 421_ LLQDL 426_ KAGLL 431_ PSGPR 436_ PGYAA 441_ IQALL 446_ SSRGV 451_ RPVSF 456_ SDWEK 461_ LDAEE 466_ VARGQ 471_ GTGKP 476_ REKLV 481_ DPQEM 486_LRLLG
1: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver (By similarity). Also acts as a ferredoxin--NADP(+) reductase essential for coenzyme Q biosynthesis: together with FDX2, transfers the electrons required for the hydroxylation reaction performed by COQ6 (PubMed:38425362)