Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
1_MGAPA 6_ CALAL 11_ CVAVA 16_ IVAGA 21_ SSESL 26_ GTEQR 31_ VVGRA 36_ AEVPG 41_ PEPGQ 46_ QEQLV 51_ FGSGD 56_ AVELS 61_ CPPPG 66_ GGPMG 71_ PTVWV 76_ KDGTG 81_ LVPSE 86_ RVLVG 91_ PQRLQ 96_ VLNAS 101_ HEDSG 106_ AYSCR 111_ QRLTQ 116_ RVLCH 121_ FSVRV 126_ TDAPS 131_ SGDDE 136_ DGEDE 141_ AEDTG 146_ VDTGA 151_ PYWTR 156_ PERMD 161_ KKLLA 166_ VPAAN 171_ TVRFR 176_ CPAAG 181_ NPTPS 186_ ISWLK 191_ NGREF 196_ RGEHR 201_ IGGIK 206_ LRHQQ 211_ WSLVM 216_ ESVVP 221_ SDRGN 226_ YTCVV 231_ ENKFG 236_ SIRQT 241_ YTLDV 246_ LERSP 251_ HRPIL 256_ QAGLP 261_ ANQTA 266_ VLGSD 271_ VEFHC 276_ KVYSD 281_ AQPHI 286_ QWLKH 291_ VEVNG 296_ SKVGP 301_ DGTPY 306_ VTVLK 311_ TAGAN 316_ TTDKE 321_ LEVLS 326_ LHNVT 331_ FEDAG 336_ EYTCL 341_ AGNSI 346_ GFSHH 351_ SAWLV 356_ VLPAE 361_ EELVE 366_ ADEAG 371_ SVYAG 376_ ILSYG 381_ VGFFL 386_ FILVV 391_ AAVTL 396_ CRLRS 401_ PPKKG 406_ LGSPT 411_ VHKIS 416_ RFPLK 421_ RQVSL 426_ ESNAS 431_ MSSNT 436_ PLVRI 441_ ARLSS 446_ GEGPT 451_ LANVS 456_ ELELP 461_ ADPKW 466_ ELSRA 471_ RLTLG 476_ KPLGE 481_ GCFGQ 486_ VVMAE 491_ AIGID 496_ KDRAA 501_ KPVTV 506_ AVKML 511_ KDDAT 516_ DKDLS 521_ DLVSE 526_ MEMMK 531_ MIGKH 536_ KNIIN 541_ LLGAC 546_ TQGGP 551_ LYVLV 556_ EYAAK 561_ GNLRE 566_ FLRAR 571_ RPPGL 576_ DYSFD 581_ TCKPP 586_ EEQLT 591_ FKDLV 596_ SCAYQ 601_ VARGM 606_ EYLAS 611_ QKCIH 616_ RDLAA 621_ RNVLV 626_ TEDNV 631_ MKIAD 636_ FGLAR 641_ DVHNL 646_ DYYKK 651_ TTNGR 656_ LPVKW 661_ MAPEA 666_ LFDRV 671_ YTHQS 676_ DVWSF 681_ GVLLW 686_ EIFTL 691_ GGSPY 696_ PGIPV 701_ EELFK 706_ LLKEG 711_ HRMDK 716_ PANCT 721_ HDLYM 726_ IMREC 731_ WHAAP 736_ SQRPT 741_ FKQLV 746_ EDLDR 751_ VLTVT 756_ STDEY 761_ LDLSA 766_ PFEQY 771_ SPGGQ 776_ DTPSS 781_ SSSGD 786_ DSVFA 791_ HDLLP 796_ PAPPS 801_SGGSR
1: Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling