E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
1_MAGNV 6_ KKSSG 11_ AGGGS 16_ GSGGS 21_ GSGGL 26_ IGLMK 31_ DAFQP 36_ HHHHH 41_ HHLSP 46_ HPPGT 51_ VDKKM 56_ VEKCW 61_ KLMDK 66_ VVRLC 71_ QNPKL 76_ ALKNS 81_ PPYIL 86_ DLLPD 91_ TYQHL 96_ RTILS 101_ RYEGK 106_ METLG 111_ ENEYF 116_ RVFME 121_ NLMKK 126_ TKQTI 131_ SLFKE 136_ GKERM 141_ YEENS 146_ QPRRN 151_ LTKLS 156_ LIFSH 161_ MLAEL 166_ KGIFP 171_ SGLFQ 176_ GDTFR 181_ ITKAD 186_ AAEFW 191_ RKAFG 196_ EKTIV 201_ PWKSF 206_ RQALH 211_ EVHPI 216_ SSGLE 221_ AMALK 226_ STIDL 231_ TCNDY 236_ ISVFE 241_ FDIFT 246_ RLFQP 251_ WSSLL 256_ RNWNS 261_ LAVTH 266_ PGYMA 271_ FLTYD 276_ EVKAR 281_ LQKFI 286_ HKPGS 291_ YIFRL 296_ SCTRL 301_ GQWAI 306_ GYVTA 311_ DGNIL 316_ QTIPH 321_ NKPLF 326_ QALID 331_ GFREG 336_ FYLFP 341_ DGRNQ 346_ NPDLT 351_ GLCEP 356_ TPQDH 361_ IKVTQ 366_ EQYEL 371_ YCEMG 376_ STFQL 381_ CKICA 386_ ENDKD 391_ VKIEP 396_ CGHLM 401_ CTSCL 406_ TSWQE 411_ SEGQG 416_ CPFCR 421_ CEIKG 426_ TEPIV 431_ VDPFD 436_ PRGSG 441_ SLLRQ 446_ GAEGA 451_ PSPNY 456_ DDDDD 461_ ERADD 466_ TLFMM 471_ KELAG 476_ AKVER 481_ PPSPF 486_ SMAPQ 491_ ASLPP 496_ VPPRL 501_ DLLPQ 506_ RVCVP 511_ SSASA 516_ LGTAS 521_ KAASG 526_ SLHKD 531_ KPLPV 536_ PPTLR 541_ DLPPP 546_ PPPDR 551_ PYSVG 556_ AESRP 561_ QRRPL 566_ PCTPG 571_ DCPSR 576_ DKLPP 581_ VPSSR 586_ LGDSW 591_ LPRPI 596_ PKVPV 601_ SAPSS 606_ SDPWT 611_ GRELT 616_ NRHSL 621_ PFSLP 626_ SQMEP 631_ RPDVP 636_ RLGST 641_ FSLDT 646_ SMSMN 651_ SSPLV 656_ GPECD 661_ HPKIK 666_ PSSSA 671_ NAIYS 676_ LAARP 681_ LPVPK 686_ LPPGE 691_ QCEGE 696_ EDTEY 701_ MTPSS 706_ RPLRP 711_ LDTSQ 716_ SSRAC 721_ DCDQQ 726_ IDSCT 731_ YEAMY 736_ NIQSQ 741_ APSIT 746_ ESSTF 751_ GEGNL 756_ AAAHA 761_ NTGPE 766_ ESENE 771_ DDGYD 776_ VPKPP 781_ VPAVL 786_ ARRTL 791_ SDISN 796_ ASSSF 801_ GWLSL 806_ DGDPT 811_ TNVTE 816_ GSQVP 821_ ERPPK 826_ PFPRR 831_ INSER 836_ KAGSC 841_ QQGSG 846_ PAASA 851_ ATASP 856_ QLSSE 861_ IENLM 866_ SQGYS 871_ YQDIQ 876_ KALVI 881_ AQNNI 886_ EMAKN 891_ ILREF 896_ VSISS 901_PAHVA
1: E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity)