Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2)
1_MKLLT 6_ RAGSF 11_ SRFYS 16_ LKVAP 21_ KVKAT 26_ AAPAG 31_ APPQP 36_ QDLEF 41_ TKLPN 46_ GLVIA 51_ SLENY 56_ SPVSR 61_ IGLFI 66_ KAGSR 71_ YEDFS 76_ NLGTT 81_ HLLRL 86_ TSSLT 91_ TKGAS 96_ SFKIT 101_ RGIEA 106_ VGGKL 111_ SVTAT 116_ RENMA 121_ YTVEC 126_ LRGDV 131_ DILME 136_ FLLNV 141_ TTAPE 146_ FRRWE 151_ VADLQ 156_ PQLKI 161_ DKAVA 166_ FQNPQ 171_ THVIE 176_ NLHAA 181_ AYRNA 186_ LANPL 191_ YCPDY 196_ RIGKV 201_ TSEEL 206_ HYFVQ 211_ NHFTS 216_ ARMAL 221_ IGLGV 226_ SHPVL 231_ KQVAE 236_ QFLNM 241_ RGGLG 246_ LSGAK 251_ ANYRG 256_ GEIRE 261_ QNGDS 266_ LVHAA 271_ FVAES 276_ AVAGS 281_ AEANA 286_ FSVLQ 291_ HVLGA 296_ GPHVK 301_ RGSNT 306_ TSHLH 311_ QAVAK 316_ ATQQP 321_ FDVSA 326_ FNASY 331_ SDSGL 336_ FGIYT 341_ ISQAT 346_ AAGDV 351_ IKAAY 356_ NQVKT 361_ IAQGN 366_ LSNTD 371_ VQAAK 376_ NKLKA 381_ GYLMS 386_ VESSE 391_ CFLEE 396_ VGSQA 401_ LVAGS 406_ YMPPS 411_ TVLQQ 416_ IDSVA 421_ NADII 426_ NAAKK 431_ FVSGQ 436_ KSMAA 441_ SGNLG 446_HTPFV
1: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable)