Nuclear receptor subfamily 4 group A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3)
1_MPCIQ 6_ AQYGT 11_ PAPSP 16_ GPRDH 21_ LASDP 26_ LTPEF 31_ IKPTM 36_ DLASP 41_ EAAPA 46_ APTAL 51_ PSFST 56_ FMDGY 61_ TGEFD 66_ TFLYQ 71_ LPGTV 76_ QPCSS 81_ ASSSA 86_ SSTSS 91_ SSATS 96_ PASAS 101_ FKFED 106_ FQVYG 111_ CYPGP 116_ LSGPV 121_ DEALS 126_ SSGSD 131_ YYGSP 136_ CSAPS 141_ PSTPS 146_ FQPPQ 151_ LSPWD 156_ GSFGH 161_ FSPSQ 166_ TYEGL 171_ RAWTE 176_ QLPKA 181_ SGPPQ 186_ PPAFF 191_ SFSPP 196_ TGPSP 201_ SLAQS 206_ PLKLF 211_ PSQAT 216_ HQLGE 221_ GESYS 226_ MPTAF 231_ PGLAP 236_ TSPHL 241_ EGSGI 246_ LDTPV 251_ TSTKA 256_ RSGAP 261_ GGSEG 266_ RCAVC 271_ GDNAS 276_ CQHYG 281_ VRTCE 286_ GCKGF 291_ FKRTV 296_ QKNAK 301_ YICLA 306_ NKDCP 311_ VDKRR 316_ RNRCQ 321_ FCRFQ 326_ KCLAV 331_ GMVKE 336_ VVRTD 341_ SLKGR 346_ RGRLP 351_ SKPKQ 356_ PPDAS 361_ PANLL 366_ TSLVR 371_ AHLDS 376_ GPSTA 381_ KLDYS 386_ KFQEL 391_ VLPHF 396_ GKEDA 401_ GDVQQ 406_ FYDLL 411_ SGSLE 416_ VIRKW 421_ AEKIP 426_ GFAEL 431_ SPADQ 436_ DLLLE 441_ SAFLE 446_ LFILR 451_ LAYRS 456_ KPGEG 461_ KLIFC 466_ SGLVL 471_ HRLQC 476_ ARGFG 481_ DWIDS 486_ ILAFS 491_ RSLHS 496_ LLVDV 501_ PAFAC 506_ LSALV 511_ LITDR 516_ HGLQE 521_ PRRVE 526_ ELQNR 531_ IASCL 536_ KEHVA 541_ AVAGE 546_ PQPAS 551_ CLSRL 556_ LGKLP 561_ ELRTL 566_ CTQGL 571_ QRIFY 576_ LKLED 581_ LVPPP 586_ PIIDK 591_IFMDT
1: Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:8121493, PubMed:9315652). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (PubMed:18690216). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (PubMed:22983157). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (PubMed:15466594). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity)
2: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7