Carbonic anhydrase 4 (EC 4.2.1.1) (Carbonate dehydratase IV) (Carbonic anhydrase IV) (CA-IV)
1_MRMLL 6_ ALLAL 11_ SAARP 16_ SASAE 21_ SHWCY 26_ EVQAE 31_ SSNYP 36_ CLVPV 41_ KWGGN 46_ CQKDR 51_ QSPIN 56_ IVTTK 61_ AKVDK 66_ KLGRF 71_ FFSGY 76_ DKKQT 81_ WTVQN 86_ NGHSV 91_ MMLLE 96_ NKASI 101_ SGGGL 106_ PAPYQ 111_ AKQLH 116_ LHWSD 121_ LPYKG 126_ SEHSL 131_ DGEHF 136_ AMEMH 141_ IVHEK 146_ EKGTS 151_ RNVKE 156_ AQDPE 161_ DEIAV 166_ LAFLV 171_ EAGTQ 176_ VNEGF 181_ QPLVE 186_ ALSNI 191_ PKPEM 196_ STTMA 201_ ESSLL 206_ DLLPK 211_ EEKLR 216_ HYFRY 221_ LGSLT 226_ TPTCD 231_ EKVVW 236_ TVFRE 241_ PIQLH 246_ REQIL 251_ AFSQK 256_ LYYDK 261_ EQTVS 266_ MKDNV 271_ RPLQQ 276_ LGQRT 281_ VIKSG 286_ APGRP 291_ LPWAL 296_ PALLG 301_ PMLAC 306_LLAGF
1: Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH (PubMed:15563508, PubMed:16686544, PubMed:16807956, PubMed:17127057, PubMed:17314045, PubMed:17652713, PubMed:17705204, PubMed:18618712, PubMed:19186056, PubMed:19206230, PubMed:7625839). May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis (PubMed:15563508). It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid (PubMed:15563508)