DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein)
1_MAAAD 6_ GALPE 11_ AAALE 16_ QPAEL 21_ PASVR 26_ ASIER 31_ KRQRA 36_ LMLRQ 41_ ARLAA 46_ RPYSA 51_ TAAAA 56_ TGGMA 61_ NVKAA 66_ PKIID 71_ TGGGF 76_ ILEEE 81_ EEEEQ 86_ KIGKV 91_ VHQPG 96_ PVMEF 101_ DYVIC 106_ EECGK 111_ EFMDS 116_ YLMNH 121_ FDLPT 126_ CDNCR 131_ DADDK 136_ HKLIT 141_ KTEAK 146_ QEYLL 151_ KDCDL 156_ EKREP 161_ PLKFI 166_ VKKNP 171_ HHSQW 176_ GDMKL 181_ YLKLQ 186_ IVKRS 191_ LEVWG 196_ SQEAL 201_ EEAKE 206_ VRQEN 211_ REKMK 216_ QKKFD 221_ KKVKE 226_ LRRAV 231_ RSSVW 236_ KRETI 241_ VHQHE 246_ YGPEE 251_ NLEDD 256_ MYRKT 261_ CTMCG 266_HELTY
1: Involved in DNA nucleotide excision repair (NER). Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation (PubMed:19197159). During NER stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). Connects XPD/ERCC2 and XPB/ERCC3 during NER, retaining DNA near the XPB/ERCC3 active site, and stabilizing the complex in a different conformation than in transcribing TFIIH (PubMed:31253769)