Liver carboxylesterase 1 (Acyl-coenzyme A:cholesterol acyltransferase) (ACAT) (Brain carboxylesterase hBr1) (Carboxylesterase 1) (CE-1) (hCE-1) (EC 3.1.1.1) (Cholesteryl ester hydrolase) (CEH) (EC 3.1.1.13) (Cocaine carboxylesterase) (Egasyn) (HMSE) (Methylumbelliferyl-acetate deacetylase 1) (EC 3.1.1.56) (Monocyte/macrophage serine esterase) (Retinyl ester hydrolase) (REH) (Serine esterase 1) (Triacylglycerol hydrolase) (TGH)
1_MWLRA 6_ FILAT 11_ LSASA 16_ AWGHP 21_ SSPPV 26_ VDTVH 31_ GKVLG 36_ KFVSL 41_ EGFAQ 46_ PVAIF 51_ LGIPF 56_ AKPPL 61_ GPLRF 66_ TPPQP 71_ AEPWS 76_ FVKNA 81_ TSYPP 86_ MCTQD 91_ PKAGQ 96_ LLSEL 101_ FTNRK 106_ ENIPL 111_ KLSED 116_ CLYLN 121_ IYTPA 126_ DLTKK 131_ NRLPV 136_ MVWIH 141_ GGGLM 146_ VGAAS 151_ TYDGL 156_ ALAAH 161_ ENVVV 166_ VTIQY 171_ RLGIW 176_ GFFST 181_ GDEHS 186_ RGNWG 191_ HLDQV 196_ AALRW 201_ VQDNI 206_ ASFGG 211_ NPGSV 216_ TIFGE 221_ SAGGE 226_ SVSVL 231_ VLSPL 236_ AKNLF 241_ HRAIS 246_ ESGVA 251_ LTSVL 256_ VKKGD 261_ VKPLA 266_ EQIAI 271_ TAGCK 276_ TTTSA 281_ VMVHC 286_ LRQKT 291_ EEELL 296_ ETTLK 301_ MKFLS 306_ LDLQG 311_ DPRES 316_ QPLLG 321_ TVIDG 326_ MLLLK 331_ TPEEL 336_ QAERN 341_ FHTVP 346_ YMVGI 351_ NKQEF 356_ GWLIP 361_ MQLMS 366_ YPLSE 371_ GQLDQ 376_ KTAMS 381_ LLWKS 386_ YPLVC 391_ IAKEL 396_ IPEAT 401_ EKYLG 406_ GTDDT 411_ VKKKD 416_ LFLDL 421_ IADVM 426_ FGVPS 431_ VIVAR 436_ NHRDA 441_ GAPTY 446_ MYEFQ 451_ YRPSF 456_ SSDMK 461_ PKTVI 466_ GDHGD 471_ ELFSV 476_ FGAPF 481_ LKEGA 486_ SEEEI 491_ RLSKM 496_ VMKFW 501_ ANFAR 506_ NGNPN 511_ GEGLP 516_ HWPEY 521_ NQKEG 526_ YLQIG 531_ ANTQA 536_ AQKLK 541_ DKEVA 546_ FWTNL 551_ FAKKA 556_ VEKPP 561_QTEHI
1: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:18762277, PubMed:7980644, PubMed:9169443, PubMed:9490062). Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester (PubMed:18762277, PubMed:7980644, PubMed:9169443, PubMed:9490062). Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine (PubMed:7980644). Catalyzes the transesterification of cocaine to form cocaethylene (PubMed:7980644). Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate (PubMed:7980644). Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984). Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process (PubMed:11015575, PubMed:16024911, PubMed:16971496, PubMed:18762277). First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile (PubMed:16971496, PubMed:18599737, PubMed:18762277)