Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o)
1_MEDEV 6_ VRFAK 11_ KMDKM 16_ VQKKN 21_ AAGAL 26_ DLLKE 31_ LKNIP 36_ MTLEL 41_ LQSTR 46_ IGMSV 51_ NAIRK 56_ QSTDE 61_ EVTSL 66_ AKSLI 71_ KSWKK 76_ LLDGP 81_ STEKD 86_ LDEKK 91_ KEPAI 96_ TSQNS 101_ PEARE 106_ ESTSS 111_ GNVSN 116_ RKDET 121_ NARDT 126_ YVSSF 131_ PRAPS 136_ TSDSV 141_ RLKCR 146_ EMLAA 151_ ALRTG 156_ DDYIA 161_ IGADE 166_ EELGS 171_ QIEEA 176_ IYQEI 181_ RNTDM 186_ KYKNR 191_ VRSRI 196_ SNLKD 201_ AKNPN 206_ LRKNV 211_ LCGNI 216_ PPDLF 221_ ARMTA 226_ EEMAS 231_ DELKE 236_ MRKNL 241_ TKEAI 246_ REHQM 251_ AKTGG 256_ TQTDL 261_ FTCGK 266_ CKKKN 271_ CTYTQ 276_ VQTRS 281_ ADEPM 286_ TTFVV 291_ CNECG 296_NRWKF
1: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus