Prostaglandin G/H synthase 1 (EC 1.14.99.1) (Cyclooxygenase-1) (COX-1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1) (Prostaglandin-endoperoxide synthase 1)
1_MSRSL 6_ LLWFL 11_ LFLLL 16_ LPPLP 21_ VLLAD 26_ PGAPT 31_ PVNPC 36_ CYYPC 41_ QHQGI 46_ CVRFG 51_ LDRYQ 56_ CDCTR 61_ TGYSG 66_ PNCTI 71_ PGLWT 76_ WLRNS 81_ LRPSP 86_ SFTHF 91_ LLTHG 96_ RWFWE 101_ FVNAT 106_ FIREM 111_ LMRLV 116_ LTVRS 121_ NLIPS 126_ PPTYN 131_ SAHDY 136_ ISWES 141_ FSNVS 146_ YYTRI 151_ LPSVP 156_ KDCPT 161_ PMGTK 166_ GKKQL 171_ PDAQL 176_ LARRF 181_ LLRRK 186_ FIPDP 191_ QGTNL 196_ MFAFF 201_ AQHFT 206_ HQFFK 211_ TSGKM 216_ GPGFT 221_ KALGH 226_ GVDLG 231_ HIYGD 236_ NLERQ 241_ YQLRL 246_ FKDGK 251_ LKYQV 256_ LDGEM 261_ YPPSV 266_ EEAPV 271_ LMHYP 276_ RGIPP 281_ QSQMA 286_ VGQEV 291_ FGLLP 296_ GLMLY 301_ ATLWL 306_ REHNR 311_ VCDLL 316_ KAEHP 321_ TWGDE 326_ QLFQT 331_ TRLIL 336_ IGETI 341_ KIVIE 346_ EYVQQ 351_ LSGYF 356_ LQLKF 361_ DPELL 366_ FGVQF 371_ QYRNR 376_ IAMEF 381_ NHLYH 386_ WHPLM 391_ PDSFK 396_ VGSQE 401_ YSYEQ 406_ FLFNT 411_ SMLVD 416_ YGVEA 421_ LVDAF 426_ SRQIA 431_ GRIGG 436_ GRNMD 441_ HHILH 446_ VAVDV 451_ IRESR 456_ EMRLQ 461_ PFNEY 466_ RKRFG 471_ MKPYT 476_ SFQEL 481_ VGEKE 486_ MAAEL 491_ EELYG 496_ DIDAL 501_ EFYPG 506_ LLLEK 511_ CHPNS 516_ IFGES 521_ MIEIG 526_ APFSL 531_ KGLLG 536_ NPICS 541_ PEYWK 546_ PSTFG 551_ GEVGF 556_ NIVKT 561_ ATLKK 566_ LVCLN 571_ TKTCP 576_ YVSFR 581_ VPDAS 586_ QDDGP 591_AVERP
1: Dual cyclooxygenase and peroxidase that plays an important role in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons (PubMed:7947975). Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (Probable). Can also use linoleate (LA, (9Z,12Z)-octadecadienoate, C18:2(n-6)) as substrate and produce hydroxyoctadecadienoates (HODEs) in a regio- and stereospecific manner, being (9R)-HODE ((9R)-hydroxy-(10E,12Z)-octadecadienoate) and (13S)-HODE ((13S)-hydroxy-(9Z,11E)-octadecadienoate) its major products (By similarity)