Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6 (Alpha6p)]
1_MAAAG 6_ QLCLL 11_ YLSAG 16_ LLSRL 21_ GAAFN 26_ LDTRE 31_ DNVIR 36_ KYGDP 41_ GSLFG 46_ FSLAM 51_ HWQLQ 56_ PEDKR 61_ LLLVG 66_ APRAE 71_ ALPLQ 76_ RANRT 81_ GGLYS 86_ CDITA 91_ RGPCT 96_ RIEFD 101_ NDADP 106_ TSESK 111_ EDQWM 116_ GVTVQ 121_ SQGPG 126_ GKVVT 131_ CAHRY 136_ EKRQH 141_ VNTKQ 146_ ESRDI 151_ FGRCY 156_ VLSQN 161_ LRIED 166_ DMDGG 171_ DWSFC 176_ DGRLR 181_ GHEKF 186_ GSCQQ 191_ GVAAT 196_ FTKDF 201_ HYIVF 206_ GAPGT 211_ YNWKG 216_ IVRVE 221_ QKNNT 226_ FFDMN 231_ IFEDG 236_ PYEVG 241_ GETEH 246_ DESLV 251_ PVPAN 256_ SYLGL 261_ LFLTS 266_ VSYTD 271_ PDQFV 276_ YKTRP 281_ PREQP 286_ DTFPD 291_ VMMNS 296_ YLGFS 301_ LDSGK 306_ GIVSK 311_ DEITF 316_ VSGAP 321_ RANHS 326_ GAVVL 331_ LKRDM 336_ KSAHL 341_ LPEHI 346_ FDGEG 351_ LASSF 356_ GYDVA 361_ VVDLN 366_ KDGWQ 371_ DIVIG 376_ APQYF 381_ DRDGE 386_ VGGAV 391_ YVYMN 396_ QQGRW 401_ NNVKP 406_ IRLNG 411_ TKDSM 416_ FGIAV 421_ KNIGD 426_ INQDG 431_ YPDIA 436_ VGAPY 441_ DDLGK 446_ VFIYH 451_ GSANG 456_ INTKP 461_ TQVLK 466_ GISPY 471_ FGYSI 476_ AGNMD 481_ LDRNS 486_ YPDVA 491_ VGSLS 496_ DSVTI 501_ FRSRP 506_ VINIQ 511_ KTITV 516_ TPNRI 521_ DLRQK 526_ TACGA 531_ PSGIC 536_ LQVKS 541_ CFEYT 546_ ANPAG 551_ YNPSI 556_ SIVGT 561_ LEAEK 566_ ERRKS 571_ GLSSR 576_ VQFRN 581_ QGSEP 586_ KYTQE 591_ LTLKR 596_ QKQKV 601_ CMEET 606_ LWLQD 611_ NIRDK 616_ LRPIP 621_ ITASV 626_ EIQEP 631_ SSRRR 636_ VNSLP 641_ EVLPI 646_ LNSDE 651_ PKTAH 656_ IDVHF 661_ LKEGC 666_ GDDNV 671_ CNSNL 676_ KLEYK 681_ FCTRE 686_ GNQDK 691_ FSYLP 696_ IQKGV 701_ PELVL 706_ KDQKD 711_ IALEI 716_ TVTNS 721_ PSNPR 726_ NPTKD 731_ GDDAH 736_ EAKLI 741_ ATFPD 746_ TLTYS 751_ AYREL 756_ RAFPE 761_ KQLSC 766_ VANQN 771_ GSQAD 776_ CELGN 781_ PFKRN 786_ SNVTF 791_ YLVLS 796_ TTEVT 801_ FDTPD 806_ LDINL 811_ KLETT 816_ SNQDN 821_ LAPIT 826_ AKAKV 831_ VIELL 836_ LSVSG 841_ VAKPS 846_ QVYFG 851_ GTVVG 856_ EQAMK 861_ SEDEV 866_ GSLIE 871_ YEFRV 876_ INLGK 881_ PLTNL 886_ GTATL 891_ NIQWP 896_ KEISN 901_ GKWLL 906_ YLVKV 911_ ESKGL 916_ EKVTC 921_ EPQKE 926_ INSLN 931_ LTESH 936_ NSRKK 941_ REITE 946_ KQIDD 951_ NRKFS 956_ LFAER 961_ KYQTL 966_ NCSVN 971_ VNCVN 976_ IRCPL 981_ RGLDS 986_ KASLI 991_ LRSRL 996_ WNSTF 1001_ LEEYS 1006_ KLNYL 1011_ DILMR 1016_ AFIDV 1021_ TAAAE 1026_ NIRLP 1031_ NAGTQ 1036_ VRVTV 1041_ FPSKT 1046_ VAQYS 1051_ GVPWW 1056_ IILVA 1061_ ILAGI 1066_ LMLAL 1071_ LVFIL 1076_ WKCGF 1081_ FKRSR 1086_ YDDSV 1091_ PRYHA 1096_ VRIRK 1101_ EEREI 1106_ KDEKY 1111_ IDNLE 1116_ KKQWI 1121_TKWNE
1: Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464)