Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS]
1_MPNSE 6_ PASLL 11_ ELFNS 16_ IATQG 21_ ELVRS 26_ LKAGN 31_ ASKDE 36_ IDSAV 41_ KMLVS 46_ LKMSY 51_ KAAAG 56_ EDYKA 61_ DCPPG 66_ NPAPT 71_ SNHGP 76_ DATEA 81_ EEDFV 86_ DPWTV 91_ QTSSA 96_ KGIDY 101_ DKLIV 106_ RFGSS 111_ KIDKE 116_ LINRI 121_ ERATG 126_ QRPHH 131_ FLRRG 136_ IFFSH 141_ RDMNQ 146_ VLDAY 151_ ENKKP 156_ FYLYT 161_ GRGPS 166_ SEAMH 171_ VGHLI 176_ PFIFT 181_ KWLQD 186_ VFNVP 191_ LVIQM 196_ TDDEK 201_ YLWKD 206_ LTLDQ 211_ AYSYA 216_ VENAK 221_ DIIAC 226_ GFDIN 231_ KTFIF 236_ SDLDY 241_ MGMSS 246_ GFYKN 251_ VVKIQ 256_ KHVTF 261_ NQVKG 266_ IFGFT 271_ DSDCI 276_ GKISF 281_ PAIQA 286_ APSFS 291_ NSFPQ 296_ IFRDR 301_ TDIQC 306_ LIPCA 311_ IDQDP 316_ YFRMT 321_ RDVAP 326_ RIGYP 331_ KPALL 336_ HSTFF 341_ PALQG 346_ AQTKM 351_ SASDP 356_ NSSIF 361_ LTDTA 366_ KQIKT 371_ KVNKH 376_ AFSGG 381_ RDTIE 386_ EHRQF 391_ GGNCD 396_ VDVSF 401_ MYLTF 406_ FLEDD 411_ DKLEQ 416_ IRKDY 421_ TSGAM 426_ LTGEL 431_ KKALI 436_ EVLQP 441_ LIAEH 446_ QARRK 451_ EVTDE 456_ IVKEF 461_ MTPRK 466_LSFDF
1: Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp)
2: Has no angiostatic activity
3: Possesses an angiostatic activity but has no aminoacylation activity (PubMed:11773625, PubMed:11773626, PubMed:14630953). Inhibits fluid shear stress-activated responses of endothelial cells (PubMed:14630953). Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (PubMed:14630953)
4: Has an angiostatic activity