Glycine receptor subunit alpha-1 (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit)
1_MYSFN 6_ TLRLY 11_ LWETI 16_ VFFSL 21_ AASKE 26_ AEAAR 31_ SAPKP 36_ MSPSD 41_ FLDKL 46_ MGRTS 51_ GYDAR 56_ IRPNF 61_ KGPPV 66_ NVSCN 71_ IFINS 76_ FGSIA 81_ ETTMD 86_ YRVNI 91_ FLRQQ 96_ WNDPR 101_ LAYNE 106_ YPDDS 111_ LDLDP 116_ SMLDS 121_ IWKPD 126_ LFFAN 131_ EKGAH 136_ FHEIT 141_ TDNKL 146_ LRISR 151_ NGNVL 156_ YSIRI 161_ TLTLA 166_ CPMDL 171_ KNFPM 176_ DVQTC 181_ IMQLE 186_ SFGYT 191_ MNDLI 196_ FEWQE 201_ QGAVQ 206_ VADGL 211_ TLPQF 216_ ILKEE 221_ KDLRY 226_ CTKHY 231_ NTGKF 236_ TCIEA 241_ RFHLE 246_ RQMGY 251_ YLIQM 256_ YIPSL 261_ LIVIL 266_ SWISF 271_ WINMD 276_ AAPAR 281_ VGLGI 286_ TTVLT 291_ MTTQS 296_ SGSRA 301_ SLPKV 306_ SYVKA 311_ IDIWM 316_ AVCLL 321_ FVFSA 326_ LLEYA 331_ AVNFV 336_ SRQHK 341_ ELLRF 346_ RRKRR 351_ HHKSP 356_ MLNLF 361_ QEDEA 366_ GEGRF 371_ NFSAY 376_ GMGPA 381_ CLQAK 386_ DGISV 391_ KGANN 396_ SNTTN 401_ PPPAP 406_ SKSPE 411_ EMRKL 416_ FIQRA 421_ KKIDK 426_ ISRIG 431_ FPMAF 436_ LIFNM 441_ FYWII 446_ YKIVR 451_REDVH
1: Subunit of heteromeric glycine-gated chloride channels (PubMed:14551753, PubMed:23994010, PubMed:25730860, PubMed:37821459). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Channel activity is potentiated by ethanol (PubMed:25973519). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity)