Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
1_MQYLN 6_ IKEDC 11_ NAMAF 16_ CAKMR 21_ SSKKT 26_ EVNLE 31_ APEPG 36_ VEVIF 41_ YLSDR 46_ EPLRL 51_ GSGEY 56_ TAEEL 61_ CIRAA 66_ QACRI 71_ SPLCH 76_ NLFAL 81_ YDENT 86_ KLWYA 91_ PNRTI 96_ TVDDK 101_ MSLRL 106_ HYRMR 111_ FYFTN 116_ WHGTN 121_ DNEQS 126_ VWRHS 131_ PKKQK 136_ NGYEK 141_ KKIPD 146_ ATPLL 151_ DASSL 156_ EYLFA 161_ QGQYD 166_ LVKCL 171_ APIRD 176_ PKTEQ 181_ DGHDI 186_ ENECL 191_ GMAVL 196_ AISHY 201_ AMMKK 206_ MQLPE 211_ LPKDI 216_ SYKRY 221_ IPETL 226_ NKSIR 231_ QRNLL 236_ TRMRI 241_ NNVFK 246_ DFLKE 251_ FNNKT 256_ ICDSS 261_ VSTHD 266_ LKVKY 271_ LATLE 276_ TLTKH 281_ YGAEI 286_ FETSM 291_ LLISS 296_ ENEMN 301_ WFHSN 306_ DGGNV 311_ LYYEV 316_ MVTGN 321_ LGIQW 326_ RHKPN 331_ VVSVE 336_ KEKNK 341_ LKRKK 346_ LENKH 351_ KKDEE 356_ KNKIR 361_ EEWNN 366_ FSYFP 371_ EITHI 376_ VIKES 381_ VVSIN 386_ KQDNK 391_ KMELK 396_ LSSHE 401_ EALSF 406_ VSLVD 411_ GYFRL 416_ TADAH 421_ HYLCT 426_ DVAPP 431_ LIVHN 436_ IQNGC 441_ HGPIC 446_ TEYAI 451_ NKLRQ 456_ EGSEE 461_ GMYVL 466_ RWSCT 471_ DFDNI 476_ LMTVT 481_ CFEKS 486_ EQVQG 491_ AQKQF 496_ KNFQI 501_ EVQKG 506_ RYSLH 511_ GSDRS 516_ FPSLG 521_ DLMSH 526_ LKKQI 531_ LRTDN 536_ ISFML 541_ KRCCQ 546_ PKPRE 551_ ISNLL 556_ VATKK 561_ AQEWQ 566_ PVYPM 571_ SQLSF 576_ DRILK 581_ KDLVQ 586_ GEHLG 591_ RGTRT 596_ HIYSG 601_ TLMDY 606_ KDDEG 611_ TSEEK 616_ KIKVI 621_ LKVLD 626_ PSHRD 631_ ISLAF 636_ FEAAS 641_ MMRQV 646_ SHKHI 651_ VYLYG 656_ VCVRD 661_ VENIM 666_ VEEFV 671_ EGGPL 676_ DLFMH 681_ RKSDV 686_ LTTPW 691_ KFKVA 696_ KQLAS 701_ ALSYL 706_ EDKDL 711_ VHGNV 716_ CTKNL 721_ LLARE 726_ GIDSE 731_ CGPFI 736_ KLSDP 741_ GIPIT 746_ VLSRQ 751_ ECIER 756_ IPWIA 761_ PECVE 766_ DSKNL 771_ SVAAD 776_ KWSFG 781_ TTLWE 786_ ICYNG 791_ EIPLK 796_ DKTLI 801_ EKERF 806_ YESRC 811_ RPVTP 816_ SCKEL 821_ ADLMT 826_ RCMNY 831_ DPNQR 836_ PFFRA 841_ IMRDI 846_ NKLEE 851_ QNPDI 856_ VSEKK 861_ PATEV 866_ DPTHF 871_ EKRFL 876_ KRIRD 881_ LGEGH 886_ FGKVE 891_ LCRYD 896_ PEGDN 901_ TGEQV 906_ AVKSL 911_ KPESG 916_ GNHIA 921_ DLKKE 926_ IEILR 931_ NLYHE 936_ NIVKY 941_ KGICT 946_ EDGGN 951_ GIKLI 956_ MEFLP 961_ SGSLK 966_ EYLPK 971_ NKNKI 976_ NLKQQ 981_ LKYAV 986_ QICKG 991_ MDYLG 996_ SRQYV 1001_ HRDLA 1006_ ARNVL 1011_ VESEH 1016_ QVKIG 1021_ DFGLT 1026_ KAIET 1031_ DKEYY 1036_ TVKDD 1041_ RDSPV 1046_ FWYAP 1051_ ECLMQ 1056_ SKFYI 1061_ ASDVW 1066_ SFGVT 1071_ LHELL 1076_ TYCDS 1081_ DSSPM 1086_ ALFLK 1091_ MIGPT 1096_ HGQMT 1101_ VTRLV 1106_ NTLKE 1111_ GKRLP 1116_ CPPNC 1121_ PDEVY 1126_ QLMRK 1131_ CWEFQ 1136_ PSNRT 1141_ SFQNL 1146_IEGFE
1: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). Kinase partner for the type I interferon receptor IFNAR2 (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins (PubMed:7759950). Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:16239216, PubMed:32750333, PubMed:8232552)