Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP)
1_MLSHG 6_ AGLAL 11_ WITLS 16_ LLQTG 21_ LAEPE 26_ RCNFT 31_ LAESK 36_ ASSHS 41_ VSIQW 46_ RILGS 51_ PCNFS 56_ LIYSS 61_ DTLGA 66_ ALCPT 71_ FRIDN 76_ TTYGC 81_ NLQDL 86_ QAGTI 91_ YNFRI 96_ ISLDE 101_ ERTVV 106_ LQTDP 111_ LPPAR 116_ FGVSK 121_ EKTTS 126_ TSLHV 131_ WWTPS 136_ SGKVT 141_ SYEVQ 146_ LFDEN 151_ NQKIQ 156_ GVQIQ 161_ ESTSW 166_ NEYTF 171_ FNLTA 176_ GSKYN 181_ IAITA 186_ VSGGK 191_ RSFSV 196_ YTNGS 201_ TVPSP 206_ VKDIG 211_ ISTKA 216_ NSLLI 221_ SWSHG 226_ SGNVE 231_ RYRLM 236_ LMDKG 241_ ILVHG 246_ GVVDK 251_ HATSY 256_ AFHGL 261_ TPGYL 266_ YNLTV 271_ MTEAA 276_ GLQNY 281_ RWKLV 286_ RTAPM 291_ EVSNL 296_ KVTND 301_ GSLTS 306_ LKVKW 311_ QRPPG 316_ NVDSY 321_ NITLS 326_ HKGTI 331_ KESRV 336_ LAPWI 341_ TETHF 346_ KELVP 351_ GRLYQ 356_ VTVSC 361_ VSGEL 366_ SAQKM 371_ AVGRT 376_ FPDKV 381_ ANLEA 386_ NNNGR 391_ MRSLV 396_ VSWSP 401_ PAGDW 406_ EQYRI 411_ LLFND 416_ SVVLL 421_ NITVG 426_ KEETQ 431_ YVMDD 436_ TGLVP 441_ GRQYE 446_ VEVIV 451_ ESGNL 456_ KNSER 461_ CQGRT 466_ VPLAV 471_ LQLRV 476_ KHANE 481_ TSLSI 486_ MWQTP 491_ VAEWE 496_ KYIIS 501_ LADRD 506_ LLLIH 511_ KSLSK 516_ DAKEF 521_ TFTDL 526_ VPGRK 531_ YMATV 536_ TSISG 541_ DLKNS 546_ SSVKG 551_ RTVPA 556_ QVTDL 561_ HVANQ 566_ GMTSS 571_ LFTNW 576_ TQAQG 581_ DVEFY 586_ QVLLI 591_ HENVV 596_ IKNES 601_ ISSET 606_ SRYSF 611_ HSLKS 616_ GSLYS 621_ VVVTT 626_ VSGGI 631_ SSRQV 636_ VVEGR 641_ TVPSS 646_ VSGVT 651_ VNNSG 656_ RNDYL 661_ SVSWL 666_ LAPGD 671_ VDNYE 676_ VTLSH 681_ DGKVV 686_ QSLVI 691_ AKSVR 696_ ECSFS 701_ SLTPG 706_ RLYTV 711_ TITTR 716_ SGKYE 721_ NHSFS 726_ QERTV 731_ PDKVQ 736_ GVSVS 741_ NSARS 746_ DYLRV 751_ SWVHA 756_ TGDFD 761_ HYEVT 766_ IKNKN 771_ NFIQT 776_ KSIPK 781_ SENEC 786_ VFVQL 791_ VPGRL 796_ YSVTV 801_ TTKSG 806_ QYEAN 811_ EQGNG 816_ RTIPE 821_ PVKDL 826_ TLRNR 831_ STEDL 836_ HVTWS 841_ GANGD 846_ VDQYE 851_ IQLLF 856_ NDMKV 861_ FPPFH 866_ LVNTA 871_ TEYRF 876_ TSLTP 881_ GRQYK 886_ ILVLT 891_ ISGDV 896_ QQSAF 901_ IEGFT 906_ VPSAV 911_ KNIHI 916_ SPNGA 921_ TDSLT 926_ VNWTP 931_ GGGDV 936_ DSYTV 941_ SAFRH 946_ SQKVD 951_ SQTIP 956_ KHVFE 961_ HTFHR 966_ LEAGE 971_ QYQIM 976_ IASVS 981_ GSLKN 986_ QINVV 991_ GRTVP 996_ ASVQG 1001_ VIADN 1006_ AYSSY 1011_ SLIVS 1016_ WQKAA 1021_ GVAER 1026_ YDILL 1031_ LTENG 1036_ ILLRN 1041_ TSEPA 1046_ TTKQH 1051_ KFEDL 1056_ TPGKK 1061_ YKIQI 1066_ LTVSG 1071_ GLFSK 1076_ EAQTE 1081_ GRTVP 1086_ AAVTD 1091_ LRITE 1096_ NSTRH 1101_ LSFRW 1106_ TASEG 1111_ ELSWY 1116_ NIFLY 1121_ NPDGN 1126_ LQERA 1131_ QVDPL 1136_ VQSFS 1141_ FQNLL 1146_ QGRMY 1151_ KMVIV 1156_ THSGE 1161_ LSNES 1166_ FIFGR 1171_ TVPAS 1176_ VSHLR 1181_ GSNRN 1186_ TTDSL 1191_ WFNWS 1196_ PASGD 1201_ FDFYE 1206_ LILYN 1211_ PNGTK 1216_ KENWK 1221_ DKDLT 1226_ EWRFQ 1231_ GLVPG 1236_ RKYVL 1241_ WVVTH 1246_ SGDLS 1251_ NKVTA 1256_ ESRTA 1261_ PSPPS 1266_ LMSFA 1271_ DIANT 1276_ SLAIT 1281_ WKGPP 1286_ DWTDY 1291_ NDFEL 1296_ QWLPR 1301_ DALTV 1306_ FNPYN 1311_ NRKSE 1316_ GRIVY 1321_ GLRPG 1326_ RSYQF 1331_ NVKTV 1336_ SGDSW 1341_ KTYSK 1346_ PIFGS 1351_ VRTKP 1356_ DKIQN 1361_ LHCRP 1366_ QNSTA 1371_ IACSW 1376_ IPPDS 1381_ DFDGY 1386_ SIECR 1391_ KMDTQ 1396_ EVEFS 1401_ RKLEK 1406_ EKSLL 1411_ NIMML 1416_ VPHKR 1421_ YLVSI 1426_ KVQSA 1431_ GMTSE 1436_ VVEDS 1441_ TITMI 1446_ DRPPP 1451_ PPPHI 1456_ RVNEK 1461_ DVLIS 1466_ KSSIN 1471_ FTVNC 1476_ SWFSD 1481_ TNGAV 1486_ KYFTV 1491_ VVREA 1496_ DGSDE 1501_ LKPEQ 1506_ QHPLP 1511_ SYLEY 1516_ RHNAS 1521_ IRVYQ 1526_ TNYFA 1531_ SKCAE 1536_ NPNSN 1541_ SKSFN 1546_ IKLGA 1551_ EMESL 1556_ GGKCD 1561_ PTQQK 1566_ FCDGP 1571_ LKPHT 1576_ AYRIS 1581_ IRAFT 1586_ QLFDE 1591_ DLKEF 1596_ TKPLY 1601_ SDTFF 1606_ SLPIT 1611_ TESEP 1616_ LFGAI 1621_ EGVSA 1626_ GLFLI 1631_ GMLVA 1636_ VVALL 1641_ ICRQK 1646_ VSHGR 1651_ ERPSA 1656_ RLSIR 1661_ RDRPL 1666_ SVHLN 1671_ LGQKG 1676_ NRKTS 1681_ CPIKI 1686_ NQFEG 1691_ HFMKL 1696_ QADSN 1701_ YLLSK 1706_ EYEEL 1711_ KDVGR 1716_ NQSCD 1721_ IALLP 1726_ ENRGK 1731_ NRYNN 1736_ ILPYD 1741_ ATRVK 1746_ LSNVD 1751_ DDPCS 1756_ DYINA 1761_ SYIPG 1766_ NNFRR 1771_ EYIVT 1776_ QGPLP 1781_ GTKDD 1786_ FWKMV 1791_ WEQNV 1796_ HNIVM 1801_ VTQCV 1806_ EKGRV 1811_ KCDHY 1816_ WPADQ 1821_ DSLYY 1826_ GDLIL 1831_ QMLSE 1836_ SVLPE 1841_ WTIRE 1846_ FKICG 1851_ EEQLD 1856_ AHRLI 1861_ RHFHY 1866_ TVWPD 1871_ HGVPE 1876_ TTQSL 1881_ IQFVR 1886_ TVRDY 1891_ INRSP 1896_ GAGPT 1901_ VVHCS 1906_ AGVGR 1911_ TGTFI 1916_ ALDRI 1921_ LQQLD 1926_ SKDSV 1931_ DIYGA 1936_ VHDLR 1941_ LHRVH 1946_ MVQTE 1951_ CQYVY 1956_ LHQCV 1961_ RDVLR 1966_ ARKLR 1971_ SEQEN 1976_ PLFPI 1981_ YENVN 1986_ PEYHR 1991_DPVYS
1: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity)