Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48)
1_MEPLC 6_ PLLLV 11_ GFSLP 16_ LARAL 21_ RGNET 26_ TADSN 31_ ETTTT 36_ SGPPD 41_ PGASQ 46_ PLLAW 51_ LLLPL 56_ LLLLL 61_ VLLLA 66_ AYFFR 71_ FRKQR 76_ KAVVS 81_ TSDKK 86_ MPNGI 91_ LEEQE 96_ QQRVM 101_ LLSRS 106_ PSGPK 111_ KYFPI 116_ PVEHL 121_ EEEIR 126_ IRSAD 131_ DCKQF 136_ REEFN 141_ SLPSG 146_ HIQGT 151_ FELAN 156_ KEENR 161_ EKNRY 166_ PNILP 171_ NDHSR 176_ VILSQ 181_ LDGIP 186_ CSDYI 191_ NASYI 196_ DGYKE 201_ KNKFI 206_ AAQGP 211_ KQETV 216_ NDFWR 221_ MVWEQ 226_ KSATI 231_ VMLTN 236_ LKERK 241_ EEKCH 246_ QYWPD 251_ QGCWT 256_ YGNIR 261_ VCVED 266_ CVVLV 271_ DYTIR 276_ KFCIQ 281_ PQLPD 286_ GCKAP 291_ RLVSQ 296_ LHFTS 301_ WPDFG 306_ VPFTP 311_ IGMLK 316_ FLKKV 321_ KTLNP 326_ VHAGP 331_ IVVHC 336_ SAGVG 341_ RTGTF 346_ IVIDA 351_ MMAMM 356_ HAEQK 361_ VDVFE 366_ FVSRI 371_ RNQRP 376_ QMVQT 381_ DMQYT 386_ FIYQA 391_ LLEYY 396_ LYGDT 401_ ELDVS 406_ SLEKH 411_ LQTMH 416_ GTTTH 421_ FDKIG 426_ LEEEF 431_ RKLTN 436_ VRIMK 441_ ENMRT 446_ GNLPA 451_ NMKKA 456_ RVIQI 461_ IPYDF 466_ NRVIL 471_ SMKRG 476_ QEYTD 481_ YINAS 486_ FIDGY 491_ RQKDY 496_ FIATQ 501_ GPLAH 506_ TVEDF 511_ WRMIW 516_ EWKSH 521_ TIVML 526_ TEVQE 531_ REQDK 536_ CYQYW 541_ PTEGS 546_ VTHGE 551_ ITIEI 556_ KNDTL 561_ SEAIS 566_ IRDFL 571_ VTLNQ 576_ PQARQ 581_ EEQVR 586_ VVRQF 591_ HFHGW 596_ PEIGI 601_ PAEGK 606_ GMIDL 611_ IAAVQ 616_ KQQQQ 621_ TGNHP 626_ ITVHC 631_ SAGAG 636_ RTGTF 641_ IALSN 646_ ILERV 651_ KAEGL 656_ LDVFQ 661_ AVKSL 666_ RLQRP 671_ HMVQT 676_ LEQYE 681_ FCYKV 686_ VQDFI 691_DIFSD
1: Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity)
2: Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity)
3: Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+)