Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa)
1_MAGGG 6_ GDLST 11_ RRLNE 16_ CISPV 21_ ANEMN 26_ HLPAH 31_ SHDLQ 36_ RMFTE 41_ DQGVD 46_ DRLLY 51_ DIVFK 56_ HFKRN 61_ KVEIS 66_ NAIKK 71_ TFPFL 76_ EGLRD 81_ RDLIT 86_ NKMFE 91_ DSQDS 96_ CRNLV 101_ PVQRV 106_ VYNVL 111_ SELEK 116_ TFNLP 121_ VLEAL 126_ FSDVN 131_ MQEYP 136_ DLIHI 141_ YKGFE 146_ NVIHD 151_ KLPLQ 156_ ESEEE 161_ EREER 166_ SGLQL 171_ SLEQG 176_ TGENS 181_ FRSLT 186_ WPPSG 191_ SPSHA 196_ GTTPP 201_ ENGLS 206_ EHPCE 211_ TEQIN 216_ AKRKD 221_ TTSDK 226_ DDSLG 231_ SQQTN 236_ EQCAQ 241_ KAEPT 246_ ESCEQ 251_ IAVQV 256_ NNGDA 261_ GREMP 266_ CPLPC 271_ DEESP 276_ EAELH 281_ NHGIQ 286_ INSCS 291_ VRLVD 296_ IKKEK 301_ PFSNS 306_ KVECQ 311_ AQART 316_ HHNQA 321_ SDIIV 326_ ISSED 331_ SEGST 336_ DVDEP 341_ LEVFI 346_ SAPRS 351_ EPVIN 356_ NDNPL 361_ ESNDE 366_ KEGQE 371_ ATCSR 376_ PQIVP 381_ EPMDF 386_ RKLST 391_ FRESF 396_ KKRVI 401_ GQDHD 406_ FSESS 411_ EEEAP 416_ AEASS 421_ GALRS 426_ KHGEK 431_ APMTS 436_ RSTST 441_ WRIPS 446_ RKRRF 451_ SSSDF 456_ SDLSN 461_ GEELQ 466_ ETCSS 471_ SLRRG 476_ SGSQP 481_ QEPEN 486_ KKCSC 491_ VMCFP 496_ KGVPR 501_ SQEAR 506_ TESSQ 511_ ASDMM 516_ DTMDV 521_ ENNST 526_ LEKHS 531_ GKRRK 536_ KRRHR 541_ SKVNG 546_ LQRGR 551_ KKDRP 556_ RKHLT 561_ LNNKV 566_ QKKRW 571_ QQRGR 576_ KANTR 581_ PLKRR 586_ RKRGP 591_ RIPKD 596_ ENINF 601_ KQSEL 606_ PVTCG 611_ EVKGT 616_ LYKER 621_ FKQGT 626_ SKKCI 631_ QSEDK 636_ KWFTP 641_ REFEI 646_ EGDRG 651_ ASKNW 656_ KLSIR 661_ CGGYT 666_ LKVLM 671_ ENKFL 676_ PEPPS 681_ TRKKR 686_ ILESH 691_ NNTLV 696_ DPCEE 701_ HKKKN 706_ PDASV 711_ KFSEF 716_ LKKCS 721_ ETWKT 726_ IFAKE 731_ KGKFE 736_ DMAKA 741_ DKAHY 746_ EREMK 751_ TYIPP 756_ KGEKK 761_ KKFKD 766_ PNAPK 771_ RPPLA 776_ FFLFC 781_ SEYRP 786_ KIKGE 791_ HPGLS 796_ IDDVV 801_ KKLAG 806_ MWNNT 811_ AAADK 816_ QFYEK 821_ KAAKL 826_ KEKYK 831_ KDIAA 836_ YRAKG 841_ KPNSA 846_ KKRVV 851_ KAEKS 856_ KKKKE 861_ EEEDE 866_ EDEQE 871_EENEE
1: Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation