Colorectal mutant cancer protein (Protein MCC)
1_MNSGV 6_ AMKYG 11_ NDSSA 16_ ELSEL 21_ HSAAL 26_ ASLKG 31_ DIVEL 36_ NKRLQ 41_ QTERE 46_ RDLLE 51_ KKLAK 56_ AQCEQ 61_ SHLMR 66_ EHEDV 71_ QERTT 76_ LRYEE 81_ RITEL 86_ HSVIA 91_ ELNKK 96_ IDRLQ 101_ GTTIR 106_ EEDEY 111_ SELRS 116_ ELSQS 121_ QHEVN 126_ EDSRS 131_ MDQDQ 136_ TSVSI 141_ PENQS 146_ TMVTA 151_ DMDNC 156_ SDLNS 161_ ELQRV 166_ LTGLE 171_ NVVCG 176_ RKKSS 181_ CSLSV 186_ AEVDK 191_ HIEQL 196_ TTASE 201_ HCDLA 206_ IKTVE 211_ EIEGV 216_ LGRDL 221_ YPNLA 226_ EERSR 231_ WEKEL 236_ AGLRE 241_ ENESL 246_ TAMLC 251_ SKEEE 256_ LNRTK 261_ ATMNA 266_ IREER 271_ DRLRR 276_ RVREL 281_ QTRLQ 286_ SVQAT 291_ GPSSP 296_ GRLTS 301_ TNRPI 306_ NPSTG 311_ ELSTS 316_ SSSND 321_ IPIAK 326_ IAERV 331_ KLSKT 336_ RSESS 341_ SSDRP 346_ VLGSE 351_ ISSIG 356_ VSSSV 361_ AEHLA 366_ HSLQD 371_ CSNIQ 376_ EIFQT 381_ LYSHG 386_ SAISE 391_ SKIRE 396_ FEVET 401_ ERLNS 406_ RIEHL 411_ KSQND 416_ LLTIT 421_ LEECK 426_ SNAER 431_ MSMLV 436_ GKYES 441_ NATAL 446_ RLALQ 451_ YSEQC 456_ IEAYE 461_ LLLAL 466_ AESEQ 471_ SLILG 476_ QFRAA 481_ GVGSS 486_ PGDQS 491_ GDENI 496_ TQMLK 501_ RAHDC 506_ RKTAE 511_ NAAKA 516_ LLMKL 521_ DGSCG 526_ GAFAV 531_ AGCSV 536_ QPWES 541_ LSSNS 546_ HTSTT 551_ SSTAS 556_ SCDTE 561_ FTKED 566_ EQRLK 571_ DYIQQ 576_ LKNDR 581_ AAVKL 586_ TMLEL 591_ ESIHI 596_ DPLSY 601_ DVKPR 606_ GDSQR 611_ LDLEN 616_ AVLMQ 621_ ELMAM 626_ KEEMA 631_ ELKAQ 636_ LYLLE 641_ KEKKA 646_ LELKL 651_ STREA 656_ QEQAY 661_ LVHIE 666_ HLKSE 671_ VEEQK 676_ EQRMR 681_ SLSST 686_ SSGSK 691_ DKPGK 696_ ECADA 701_ ASPAL 706_ SLAEL 711_ RTTCS 716_ ENELA 721_ AEFTN 726_ AIRRE 731_ KKLKA 736_ RVQEL 741_ VSALE 746_ RLTKS 751_ SEIRH 756_ QQSAE 761_ FVNDL 766_ KRANS 771_ NLVAA 776_ YEKAK 781_ KKHQN 786_ KLKKL 791_ ESQMM 796_ AMVER 801_ HETQV 806_ RMLKQ 811_ RIALL 816_ EEENS 821_RPHTN
1: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780)