Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)
1_MASGV 6_ AVSDG 11_ VIKVF 16_ NDMKV 21_ RKSST 26_ PEEVK 31_ KRKKA 36_ VLFCL 41_ SEDKK 46_ NIILE 51_ EGKEI 56_ LVGDV 61_ GQTVD 66_ DPYAT 71_ FVKML 76_ PDKDC 81_ RYALY 86_ DATYE 91_ TKESK 96_ KEDLV 101_ FIFWA 106_ PESAP 111_ LKSKM 116_ IYASS 121_ KDAIK 126_ KKLTG 131_ IKHEL 136_ QANCY 141_ EEVKD 146_ RCTLA 151_ EKLGG 156_ SAVIS 161_LEGKP
1: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11812157). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:15580268). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed:21834987). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity)