40-kDa huntingtin-associated protein (HAP40) (CpG island protein) (Factor VIII intron 22 protein)
1_MAAAA 6_ AGLGG 11_ GGAGP 16_ GPEAG 21_ DFLAR 26_ YRLVS 31_ NKLKK 36_ RFLRK 41_ PNVAE 46_ AGEQF 51_ GQLGR 56_ ELRAQ 61_ ECLPY 66_ AAWCQ 71_ LAVAR 76_ CQQAL 81_ FHGPG 86_ EALAL 91_ TEAAR 96_ LFLRQ 101_ ERDAR 106_ QRLVC 111_ PAAYG 116_ EPLQA 121_ AASAL 126_ GAAVR 131_ LHLEL 136_ GQPAA 141_ AAALC 146_ LELAA 151_ ALRDL 156_ GQPAA 161_ AAGHF 166_ QRAAQ 171_ LQLPQ 176_ LPLAA 181_ LQALG 186_ EAASC 191_ QLLAR 196_ DYTGA 201_ LAVFT 206_ RMQRL 211_ AREHG 216_ SHPVQ 221_ SLPPP 226_ PPPAP 231_ QPGPG 236_ ATPAL 241_ PAALL 246_ PPNSG 251_ SAAPS 256_ PAALG 261_ AFSDV 266_ LVRCE 271_ VSRVL 276_ LLLLL 281_ QPPPA 286_ KLLPE 291_ HAQTL 296_ EKYSW 301_ EAFDS 306_ HGQES 311_ SGQLP 316_ EELFL 321_ LLQSL 326_ VMATH 331_ EKDTE 336_ AIKSL 341_ QVEMW 346_ PLLTA 351_ EQNHL 356_ LHLVL 361_ QETIS 366_PSGQG
1: RAB5A effector molecule that is involved in vesicular trafficking of early endosomes (PubMed:16476778). Mediates the recruitment of HTT by RAB5A onto early endosomes. The HTT-F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility (PubMed:16476778)