Trans-acting T-cell-specific transcription factor GATA-3 (GATA-binding factor 3)
1_MEVTA 6_ DQPRW 11_ VSHHH 16_ PAVLN 21_ GQHPD 26_ THHPG 31_ LSHSY 36_ MDAAQ 41_ YPLPE 46_ EVDVL 51_ FNIDG 56_ QGNHV 61_ PPYYG 66_ NSVRA 71_ TVQRY 76_ PPTHH 81_ GSQVC 86_ RPPLL 91_ HGSLP 96_ WLDGG 101_ KALGS 106_ HHTAS 111_ PWNLS 116_ PFSKT 121_ SIHHG 126_ SPGPL 131_ SVYPP 136_ ASSSS 141_ LSGGH 146_ ASPHL 151_ FTFPP 156_ TPPKD 161_ VSPDP 166_ SLSTP 171_ GSAGS 176_ ARQDE 181_ KECLK 186_ YQVPL 191_ PDSMK 196_ LESSH 201_ SRGSM 206_ TALGG 211_ ASSST 216_ HHPIT 221_ TYPPY 226_ VPEYS 231_ SGLFP 236_ PSSLL 241_ GGSPT 246_ GFGCK 251_ SRPKA 256_ RSSTG 261_ RECVN 266_ CGATS 271_ TPLWR 276_ RDGTG 281_ HYLCN 286_ ACGLY 291_ HKMNG 296_ QNRPL 301_ IKPKR 306_ RLSAA 311_ RRAGT 316_ SCANC 321_ QTTTT 326_ TLWRR 331_ NANGD 336_ PVCNA 341_ CGLYY 346_ KLHNI 351_ NRPLT 356_ MKKEG 361_ IQTRN 366_ RKMSS 371_ KSKKC 376_ KKVHD 381_ SLEDF 386_ PKNSS 391_ FNPAA 396_ LSRHM 401_ SSLSH 406_ ISPFS 411_ HSSHM 416_ LTTPT 421_ PMHPP 426_ SSLSF 431_ GPHHP 436_SSMVT
1: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages