Carnitine O-palmitoyltransferase 2, mitochondrial (EC 2.3.1.21) (Carnitine palmitoyltransferase II) (CPT II)
1_MVPRL 6_ LLRAW 11_ PRGPA 16_ VGPGA 21_ PSRPL 26_ SAGSG 31_ PGQYL 36_ QRSIV 41_ PTMHY 46_ QDSLP 51_ RLPIP 56_ KLEDT 61_ IRRYL 66_ SAQKP 71_ LLNDG 76_ QFRKT 81_ EQFCK 86_ SFENG 91_ IGKEL 96_ HEQLV 101_ ALDKQ 106_ NKHTS 111_ YISGP 116_ WFDMY 121_ LSARD 126_ SVVLN 131_ FNPFM 136_ AFNPD 141_ PKSEY 146_ NDQLT 151_ RATNM 156_ TVSAI 161_ RFLKT 166_ LRAGL 171_ LEPEV 176_ FHLNP 181_ AKSDT 186_ ITFKR 191_ LIRFV 196_ PSSLS 201_ WYGAY 206_ LVNAY 211_ PLDMS 216_ QYFRL 221_ FNSTR 226_ LPKPS 231_ RDELF 236_ TDDKA 241_ RHLLV 246_ LRKGN 251_ FYIFD 256_ VLDQD 261_ GNIVS 266_ PSEIQ 271_ AHLKY 276_ ILSDS 281_ SPAPE 286_ FPLAY 291_ LTSEN 296_ RDIWA 301_ ELRQK 306_ LMSSG 311_ NEESL 316_ RKVDS 321_ AVFCL 326_ CLDDF 331_ PIKDL 336_ VHLSH 341_ NMLHG 346_ DGTNR 351_ WFDKS 356_ FNLII 361_ AKDGS 366_ TAVHF 371_ EHSWG 376_ DGVAV 381_ LRFFN 386_ EVFKD 391_ STQTP 396_ AVTPQ 401_ SQPAT 406_ TDSTV 411_ TVQKL 416_ NFELT 421_ DALKT 426_ GITAA 431_ KEKFD 436_ ATMKT 441_ LTIDC 446_ VQFQR 451_ GGKEF 456_ LKKQK 461_ LSPDA 466_ VAQLA 471_ FQMAF 476_ LRQYG 481_ QTVAT 486_ YESCS 491_ TAAFK 496_ HGRTE 501_ TIRPA 506_ SVYTK 511_ RCSEA 516_ FVREP 521_ SRHSA 526_ GELQQ 531_ MMVEC 536_ SKYHG 541_ QLTKE 546_ AAMGQ 551_ GFDRH 556_ LFALR 561_ HLAAA 566_ KGIIL 571_ PELYL 576_ DPAYG 581_ QINHN 586_ VLSTS 591_ TLSSP 596_ AVNLG 601_ GFAPV 606_ VSDGF 611_ GVGYA 616_ VHDNW 621_ IGCNV 626_ SSYPG 631_ RNARE 636_ FLQCV 641_ EKALE 646_ DMFDA 651_LEGKS
1: Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites (PubMed:20538056, PubMed:24780397). Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters (PubMed:20538056)