Gamma-aminobutyric acid receptor subunit rho-1 (GABA(A) receptor subunit rho-1) (GABA(C) receptor)
1_MLAVP 6_ NMRFG 11_ IFLLW 16_ WGWVL 21_ ATESR 26_ MHWPG 31_ REVHE 36_ MSKKG 41_ RPQRQ 46_ RREVH 51_ EDAHK 56_ QVSPI 61_ LRRSP 66_ DITKS 71_ PLTKS 76_ EQLLR 81_ IDDHD 86_ FSMRP 91_ GFGGP 96_ AIPVG 101_ VDVQV 106_ ESLDS 111_ ISEVD 116_ MDFTM 121_ TLYLR 126_ HYWKD 131_ ERLSF 136_ PSTNN 141_ LSMTF 146_ DGRLV 151_ KKIWV 156_ PDMFF 161_ VHSKR 166_ SFIHD 171_ TTTDN 176_ VMLRV 181_ QPDGK 186_ VLYSL 191_ RVTVT 196_ AMCNM 201_ DFSRF 206_ PLDTQ 211_ TCSLE 216_ IESYA 221_ YTEDD 226_ LMLYW 231_ KKGND 236_ SLKTD 241_ ERISL 246_ SQFLI 251_ QEFHT 256_ TTKLA 261_ FYSST 266_ GWYNR 271_ LYINF 276_ TLRRH 281_ IFFFL 286_ LQTYF 291_ PATLM 296_ VMLSW 301_ VSFWI 306_ DRRAV 311_ PARVP 316_ LGITT 321_ VLTMS 326_ TIITG 331_ VNASM 336_ PRVSY 341_ IKAVD 346_ IYLWV 351_ SFVFV 356_ FLSVL 361_ EYAAV 366_ NYLTT 371_ VQERK 376_ EQKLR 381_ EKLPC 386_ TSGLP 391_ PPRTA 396_ MLDGN 401_ YSDGE 406_ VNDLD 411_ NYMPE 416_ NGEKP 421_ DRMMV 426_ QLTLA 431_ SERSS 436_ PQRKS 441_ QRSSY 446_ VSMRI 451_ DTHAI 456_ DKYSR 461_ IIFPA 466_ AYILF 471_NLIYW
1: Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (PubMed:37659407). Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits, where GABA molecules bind at the rho intersubunit interfaces (PubMed:37659407). When activated by GABA, rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:37659407). Rho-1 subunits are primarily expressed in retina where rho-1-containing GABAARs may play a role in retinal neurotransmission (PubMed:1849271). Rho-1 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (By similarity). Rho-1 GABAARs may also contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission (By similarity)