Myeloblastin (EC 3.4.21.76) (AGP7) (C-ANCA antigen) (Leukocyte proteinase 3) (PR-3) (PR3) (Neutrophil proteinase 4) (NP-4) (P29) (Wegener autoantigen)
1_MAHRP 6_ PSPAL 11_ ASVLL 16_ ALLLS 21_ GAARA 26_ AEIVG 31_ GHEAQ 36_ PHSRP 41_ YMASL 46_ QMRGN 51_ PGSHF 56_ CGGTL 61_ IHPSF 66_ VLTAA 71_ HCLRD 76_ IPQRL 81_ VNVVL 86_ GAHNV 91_ RTQEP 96_ TQQHF 101_ SVAQV 106_ FLNNY 111_ DAENK 116_ LNDVL 121_ LIQLS 126_ SPANL 131_ SASVA 136_ TVQLP 141_ QQDQP 146_ VPHGT 151_ QCLAM 156_ GWGRV 161_ GAHDP 166_ PAQVL 171_ QELNV 176_ TVVTF 181_ FCRPH 186_ NICTF 191_ VPRRK 196_ AGICF 201_ GDSGG 206_ PLICD 211_ GIIQG 216_ IDSFV 221_ IWGCA 226_ TRLFP 231_ DFFTR 236_ VALYV 241_ DWIRS 246_ TLRRV 251_EAKGR
1: Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:2033050, PubMed:28240246, PubMed:3198760). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). Plays a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279). Triggers inflammatory processes in neutrophils by interacting with ADGRG3 upstream of F2RL1/PAR2 activation (PubMed:36302784)