Rab proteins geranylgeranyltransferase component A 1 (Choroideremia protein) (Rab escort protein 1) (REP-1) (TCD protein)
1_MADTL 6_ PSEFD 11_ VIVIG 16_ TGLPE 21_ SIIAA 26_ ACSRS 31_ GRRVL 36_ HVDSR 41_ SYYGG 46_ NWASF 51_ SFSGL 56_ LSWLK 61_ EYQEN 66_ SDIVS 71_ DSPVW 76_ QDQIL 81_ ENEEA 86_ IALSR 91_ KDKTI 96_ QHVEV 101_ FCYAS 106_ QDLHE 111_ DVEEA 116_ GALQK 121_ NHALV 126_ TSANS 131_ TEAAD 136_ SAFLP 141_ TEDES 146_ LSTMS 151_ CEMLT 156_ EQTPS 161_ SDPEN 166_ ALEVN 171_ GAEVT 176_ GEKEN 181_ HCDDK 186_ TCVPS 191_ TSAED 196_ MSENV 201_ PIAED 206_ TTEQP 211_ KKNRI 216_ TYSQI 221_ IKEGR 226_ RFNID 231_ LVSKL 236_ LYSRG 241_ LLIDL 246_ LIKSN 251_ VSRYA 256_ EFKNI 261_ TRILA 266_ FREGR 271_ VEQVP 276_ CSRAD 281_ VFNSK 286_ QLTMV 291_ EKRML 296_ MKFLT 301_ FCMEY 306_ EKYPD 311_ EYKGY 316_ EEITF 321_ YEYLK 326_ TQKLT 331_ PNLQY 336_ IVMHS 341_ IAMTS 346_ ETASS 351_ TIDGL 356_ KATKN 361_ FLHCL 366_ GRYGN 371_ TPFLF 376_ PLYGQ 381_ GELPQ 386_ CFCRM 391_ CAVFG 396_ GIYCL 401_ RHSVQ 406_ CLVVD 411_ KESRK 416_ CKAII 421_ DQFGQ 426_ RIISE 431_ HFLVE 436_ DSYFP 441_ ENMCS 446_ RVQYR 451_ QISRA 456_ VLITD 461_ RSVLK 466_ TDSDQ 471_ QISIL 476_ TVPAE 481_ EPGTF 486_ AVRVI 491_ ELCSS 496_ TMTCM 501_ KGTYL 506_ VHLTC 511_ TSSKT 516_ AREDL 521_ ESVVQ 526_ KLFVP 531_ YTEME 536_ IENEQ 541_ VEKPR 546_ ILWAL 551_ YFNMR 556_ DSSDI 561_ SRSCY 566_ NDLPS 571_ NVYVC 576_ SGPDC 581_ GLGND 586_ NAVKQ 591_ AETLF 596_ QEICP 601_ NEDFC 606_ PPPPN 611_ PEDII 616_ LDGDS 621_ LQPEA 626_ SESSA 631_ IPEAN 636_ SETFK 641_ ESTNL 646_GNLEE
1: Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation