Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
1_MGWLC 6_ SGLLF 11_ PVSCL 16_ VLLQV 21_ ASSGN 26_ MKVLQ 31_ EPTCV 36_ SDYMS 41_ ISTCE 46_ WKMNG 51_ PTNCS 56_ TELRL 61_ LYQLV 66_ FLLSE 71_ AHTCI 76_ PENNG 81_ GAGCV 86_ CHLLM 91_ DDVVS 96_ ADNYT 101_ LDLWA 106_ GQQLL 111_ WKGSF 116_ KPSEH 121_ VKPRA 126_ PGNLT 131_ VHTNV 136_ SDTLL 141_ LTWSN 146_ PYPPD 151_ NYLYN 156_ HLTYA 161_ VNIWS 166_ ENDPA 171_ DFRIY 176_ NVTYL 181_ EPSLR 186_ IAAST 191_ LKSGI 196_ SYRAR 201_ VRAWA 206_ QCYNT 211_ TWSEW 216_ SPSTK 221_ WHNSY 226_ REPFE 231_ QHLLL 236_ GVSVS 241_ CIVIL 246_ AVCLL 251_ CYVSI 256_ TKIKK 261_ EWWDQ 266_ IPNPA 271_ RSRLV 276_ AIIIQ 281_ DAQGS 286_ QWEKR 291_ SRGQE 296_ PAKCP 301_ HWKNC 306_ LTKLL 311_ PCFLE 316_ HNMKR 321_ DEDPH 326_ KAAKE 331_ MPFQG 336_ SGKSA 341_ WCPVE 346_ ISKTV 351_ LWPES 356_ ISVVR 361_ CVELF 366_ EAPVE 371_ CEEEE 376_ EVEEE 381_ KGSFC 386_ ASPES 391_ SRDDF 396_ QEGRE 401_ GIVAR 406_ LTESL 411_ FLDLL 416_ GEENG 421_ GFCQQ 426_ DMGES 431_ CLLPP 436_ SGSTS 441_ AHMPW 446_ DEFPS 451_ AGPKE 456_ APPWG 461_ KEQPL 466_ HLEPS 471_ PPASP 476_ TQSPD 481_ NLTCT 486_ ETPLV 491_ IAGNP 496_ AYRSF 501_ SNSLS 506_ QSPCP 511_ RELGP 516_ DPLLA 521_ RHLEE 526_ VEPEM 531_ PCVPQ 536_ LSEPT 541_ TVPQP 546_ EPETW 551_ EQILR 556_ RNVLQ 561_ HGAAA 566_ APVSA 571_ PTSGY 576_ QEFVH 581_ AVEQG 586_ GTQAS 591_ AVVGL 596_ GPPGE 601_ AGYKA 606_ FSSLL 611_ ASSAV 616_ SPEKC 621_ GFGAS 626_ SGEEG 631_ YKPFQ 636_ DLIPG 641_ CPGDP 646_ APVPV 651_ PLFTF 656_ GLDRE 661_ PPRSP 666_ QSSHL 671_ PSSSP 676_ EHLGL 681_ EPGEK 686_ VEDMP 691_ KPPLP 696_ QEQAT 701_ DPLVD 706_ SLGSG 711_ IVYSA 716_ LTCHL 721_ CGHLK 726_ QCHGQ 731_ EDGGQ 736_ TPVMA 741_ SPCCG 746_ CCCGD 751_ RSSPP 756_ TTPLR 761_ APDPS 766_ PGGVP 771_ LEASL 776_ CPASL 781_ APSGI 786_ SEKSK 791_ SSSSF 796_ HPAPG 801_ NAQSS 806_ SQTPK 811_ IVNFV 816_SVGPT
1: Receptor for both interleukin 4 and interleukin 13 (PubMed:17030238). Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2
2: Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells