Gene name: GADD45A

Uniprot entry:

P24522

Protein names:

Growth arrest and DNA damage-inducible protein GADD45 alpha (DNA damage-inducible transcript 1 protein) (DDIT-1)

Protein sequence:

1_MTLEE 6_ FSAGE 11_ QKTER 16_ MDKVG 21_ DALEE 26_ VLSKA 31_ LSQRT 36_ ITVGV 41_ YEAAK 46_ LLNVD 51_ PDNVV 56_ LCLLA 61_ ADEDD 66_ DRDVA 71_ LQIHF 76_ TLIQA 81_ FCCEN 86_ DINIL 91_ RVSNP 96_ GRLAE 101_ LLLLE 106_ TDAGP 111_ AASEG 116_ AEQPP 121_ DLHCV 126_ LVTNP 131_ HSSQW 136_ KDPAL 141_ SQLIC 146_ FCRES 151_ RYMDQ 156_WVPVI

Protein annotations

Protein functions:

1: In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase